From the frequency of the tubercular origin of this disease, we should, a priori, expect benefit from Iodine and its salts. Dr. Willshire speaks favourably of its internal use (see Iodum); and Mr. Rowland Hoskins§ relates a very aggravated and apparently hopeless case, which yielded to the Iodide, in doses of gr. ss. every four hours. Scam-mony was at the same time given as a purgative. Another case, illustrative of the efficacy of this salt, is related by Dr. Guerond* Dr. Copland, also, states that he has prescribed it in small doses with evident advantage. In the Acute form of the disease it is also a valuable remedy, and may be given to young children in doses of gr. j. every four hours. Dr. Coldstream bears witness to its value in subduing the symptoms indicative of a tendency to hydrocephalus, especially when occurring in scrofulous subjects. In the Convulsions attendant on Dentition, which, amongst ill-fed children, are often followed by hydrocephalus, he found great advantage from its use. He gave gr. 1/2 - gr. iij. every three or four hours in some carminative water; busters to the scalp were used at the same time.
* Gaz. Hebd. de Med., Sept. 17, 1858. Med. Times and Gaz., Jan. 4,
Brit, and For. Med. Rev., Jan. 1851.
§ Ranking's Abstract, vol. xiii p. 331.
2272. In Scrofulous Ophthalmia, the Iodide, in combination with Quinine, is one of the most efficacious remedies we possess. In Catarrhal Ophthalmia, it has also proved signally useful in the hands of Mr. Osbrey.§ Dr. Copland states that he has successfully employed the Iodide of Potassium and Iodine in Amaurosis, connected with Paralysis. Two of the cases in which it proved effectual were consequent upon apoplectic seizures. || In Sclerotitis, and in Sclero-iritis, Dr. Macdonell.¶ of Montreal, speaks highly of the efficacy of the Iodide, in doses of gr. viij. - xv. thrice daily; the statements of its efficacy are corroborated by Mr. Howard,** of the same city, who observes that, in acute Sclerotitis, he has found it a most valuable remedy, and that in Chronic cases it rarely fails. In Chronic Iritis, Mr. Howard also found the greatest benefit from the administration of the Iodide. Light but nutritious diet, and exercise in the open air, are, he adds, very necessary towards the accomplishment of a cure.
2273. Looseness of the Teeth, depending upon Periostitis of the Alveolar Processes, known by the great pain, swelling, and sponginess of the gums, is often effectually cured by the Iodide of Potassium. Dr. Graves relates an illustrative case which was completely cured by this salt, in doses of gr. x. thrice daily.
2274. In Syphilis, the Iodide has been extensively employed by Hassing, Gaunthier, Moj'sisovics, Forbes, R. Williams, Acton, Graves, Wallace, Todd, and others, who express a high opinion of its value. Sir B. Brodie, on the other hand, expresses himself doubtful of its efficacy; and Ricord altogether denied its utility. Its value, however, is at present generally admitted. The results of Dr. Hassing's* treatment are well worthy of attention. In all cases of primary Syphilis, it was employed without any apparent benefit; but in secondary and constitutional forms, the results were highly satisfactory. In 1838-9, he had under his care 250 cases of the latter class; all the patients were treated alike, on low diet, and the remedy was given in the same form to all, namely, gr. viiss., dissolved in fss. of water thrice daily. Of the 250 patients, 145 were perfectly cured; 49 imperfectly cured; and 56 derived no benefit. The mean duration of treatment was 38 days. In cases of relapse, the same system was adopted. Of 73 cases of Syphilitic pains of the bones, 65 were perfectly cured; 3 relieved; 5 derived no benefit. Of 17 cases of Syphilitic Caries and Necrosis, 6 were cured; 4 relieved; 7 derived no benefit. Of 51 cases of Syphilitic Tumours or Nodes, 6 only were cured; in 22, the tumour diminished; in 23, it produced no effect. Dr. R. B. Todd. who speaks of it in the highest terms in this class of cases, observes that, if there be anything in addition to Quinine which deserves the name of a specific, it is the Iodide of Potassium, in Syphilitic Periostitis. He adds, if you have a pure case, it acts like a charm; so that the treatment materially aids the diagnosis, for we may fairly set it down as a fact, that if the symptoms yield completely and at once to the influence of the Iodide, the disease is essentially Syphilitic. Its effect, however, is not always permanent. The same results have been observed by Acton, Williams, Wallace, and others. In Affections of the Nervous System depending on Constitutional Syphilis, the Iodide, either alone or after a course of Mercury, has been prescribed with success by Dr. Russell. Dr. H. Jackson § relates a case of Unilateral Chorea occurring in a child who gave evidence of syphilitic taint, which was cured by a prolonged use of the Iodide. In Syphilitic Diseases of the Skin, it has also proved, in the highest degree, beneficial, given in doses of gr. iij. - v., in decoction of Sarsaparilla. Mr. Acton || states that in Syphilitic Diseases of the Scalp, in Lepra, Psoriasis, and Impetigo, he has found it most efficacious; and Mr. Mayo found that Lichen, arising from Syphilis, yielded rapidly to its use. Dr. Graves considers that it is the best remedy we possess in this class of diseases. In Strictures of the Urethra connected with Gonorrhoea, Dr. Thielmann¶ extols the internal administration of the Iodide thus: - Pot. Iod. 3ijAq. Dest. fvss., M., coch. amp. j. ter in die. At the same time he orders a rigid milk diet. When Iodic symptoms present themselves, the dose is diminished.
* Amer. Journ. of Med. Sci, 1851. Dict. Pract. Med, vol. i. p. 675. Edin. Med, Journ., Dec. 1859. § Dub. Journ., vol. xxi p. 417. || Dict. Pract. Med., vol. i. p. 61.
¶ Brit. Amer. Journ. of Med. and Phys. Science, Nov. 1849.
** Pathology of the Eye, pp. 316, 340.
Dub. Journ. of Med., vol. xviii. p. 238.
* Brit. For. Med. Rev., Oct. 1845. Med. Gaz., Jan. 3, 1851. Med. Times and Gaz., Oct. 17, 1863. § Ibid.
|| Lectures on Venereal Diseases, Lancet, Jan. 16, 1846.
¶ Journ. Pract. Med. and Surg., June 16, 1859.
All mechanical means are discarded; but when the inodular of the stricture is felt externally, an ointment (3jad Ung. j.) is rubbed in along the part of the penis corresponding with the urethra.
2275. In Gout, Rheumatic Gout, and Arthritic Enlargements, the external application of a solution of the Iodide is strongly advised by Dr. Home,* who states that he has employed it constantly for eight years, and that he has invariably found it to afford relief. At the same time he advises the following mixture: - Pot. Nit. 3iv., Ant. Pot. Tart. gr. ij., Spt. Ether. Nit. fj., Aq. f xj., M. sumat. coch. amp. iij. ter in die. The local application of a solution of the Iodide is also favourably spoken of by Dr. Basham. In some cases, particularly when the disease occvirs in persons of a scrofulous diathesis, or in debilitated constitutions, or where the liver is evidently in fault, the Iodide proves an efficacious internal remedy. Dr. Robertson considers that great benefit is to be derived from its use. It should be given in small doses (gr. ij. - iij.) twice or thrice daily, with Sarsaparilla or Taraxacum.