C12H7N. A volatile oily alkaloid, obtainable from indigo and from other sources, but principally from coal tar, from which it is extensively prepared for the purpose of forming certain dyes.

Med. Prop. and Action. Sedative and antispasmodic; acting apparently in a direct manner on the nervous system, according to the researches of Dr. J. Turnbull,* who first proposed it as a therapeutic agent. The Sulphate of Aniline, which appears to be destitute of the local irritating properties of the Aniline itself, is the form in which it has been chiefly employed. One peculiarity which marks itsaction is the presence of a remarkable blue colour of the lips, tongue, and nails, together with a more or less dusky appearance of the complexion, which, however, disappears in a few hours after the medi-cine has been discontinued In some cases it occasions depression of the nervous system and headache, which are also only of a temporary nature. According to the experiments of Schuchardt on animals, it produces ana-sthesia of the hinder limbs, and lowers the temperature of the body. In large doses it is poisonous, death being preceded by violent convulsions. The blue discoloration above described is attributed by Dr. Turnbull to the formation of a colouring matter or dye, produced by the oxidation of the Anilinc in the blood. The dose of the Sulphate is gr. j. twice daily, gradually increased togr. iss. - gr. ij., in solution either with or without a few drops of dilute sulphuric acid. Its use should be intermitted for a few days, on the appearance of blueness of the lips or depression of the nervous system.

235. Therapeutic Uses

In Chorea it was first employed by Dr. Turnbull, who details the particulars of six cases in which it was successfully administered. Some of these cases were of considerable severity, and had previously resisted the action of other ordinary remedies. The dose was gradually increased from gr. j. to gr. iij. of the Sulphate thrice daily. In two cases of Epilepsy it was also used with decided benefit. In the latter disease, Dr. Anstie employed it in six cases, and also in other Chronic Convulsive Diseases. It is, he remarks, a most serious mistake to administer the Sulphate, or indeed any other sedative, in large doses, with the view to arrest convulsive muscular action. In two cases in which this agent was pushed to the extent of a large dose, a serious aggravation of the fits occurred.' In doses of gr. j., thrice daily, with an additional grain to be taken immediately on the occurrence of any prodromata of a tit, Aniline seemed materially to benefit four patients, to the extent of delaying or mitigating the paroxysm; and in three instances the fit seems to have been altogether averted for a considerable time.

* Lancet, Nov. 16th, 1861, p 469. Virchow's Archiv. xx., 1801.

Medical Times, April 5, 1862.