Hypophosphite of Soda.

PotassAe Hypophosphis. Hypophosphite of Potash. Calcis Hypophosphis. Hypophosphite of Lime.

Med. Prop. and Action. These are the principal "Alkaline Hypophosphites " which have of late years been introduced into medical practice; and as they are closely allied in medical properties and uses, they may be conveniently considered together. We must premise, however, that there is a great discrepancy in the accounts given by observers as to their therapeutical value. On the whole, the balance of evidence appears to prove that their medicinal power has been greatly overrated. The stimulant, tonic and alterative properties which they have been alleged to possess in common, are supposed to be due to the phosphorus which they contain. According to Dr. J. F. Churchill, who has brought them prominently into notice, they increase the nervous force, and are powerful hAematogens, possessing all the therapeutic properties of phosphorus, without the danger attending its use. A Hypophosphite, it is asserted, is the most soluble, in all the animal secretions, of all the oxides of phosphorus, and is at once admitted into the venous system. If pure Hypophosphite of Potash or Soda, in doses of even two grains, be given, it excites a feeling of nausea and a slight pain in the chest, much increased by repetition of the dose. It is, therefore, well to combine the salt with a mild tonic, as Tincture of Gentian, or an anodyne, as a little Morphia, otherwise a genuine Alkaline Hypophosphite is repulsive to the nerves of the stomach, and the patient refuses to take a second dose. The following are some of the formulAe employed by Mr. Taylor: - ℞ PotassAe Hypophosph. 3ss.; Spt. Lavand. Co. fss.; Aq. Cinnam. fvj.; M., coch. amp. j. ter in die. ℞ PotassAe Hypophosph. j.; Tinct. Gent. Co. fss.; Aq. Menth. Pip. fvij.; M., coch. amp. j. ter in die. As a general rule, the Soda Hypophosphite should be given in blood diseases; and that of Soda, Ammonia, or Lime, in those of the secretory organs. (Taylor, j)

Dose of the Hypophosphite of Soda, Potash, or Lime, gr. ij. - gr. xv., in a bitter infusion.

2563. Therapeutic Uses

In Phthisis, the Alkaline Hypophos-phites were introduced by Dr. Churchill as curative in every stage; the word palliative would, according to Mr. Taylor, be more in accordance with fact. Mr. Taylor believes that in the earlier and middle stages they act as a respiratory excitant; as a pyrogenic, increasing animal heat and nervous force, and removing erratic pains; and as a hAematogen, forming a nucleus for the rallying of red globules. He finds that they tend to increase the appetite and cheerfulness, and to control expectoration, night sweats, and diarrhoea. Even in the advanced stages of the disease, he states that their influence as a palliative is often very striking. Subsequent observations, however, have much shaken the faith of the profession in the alleged value of the Hypophosphites in Phthisis. They failed in the hands of Dr. Quain;* and in twenty cases in which they were fairly tried by Dr. J. R. Bennett, there were only nine in which the disease did not steadily advance whilst under treatment, or in which there was the least evidence of improvement. Of these nine, only four manifested any decided improvement, of the permanency of which there was no proof. Dr. Bennett employed the Hypophosphite of Soda in doses of gr. xv., three times a day. Dr. Cotton also employed them unsuccessfully in twelve cases; and as no benefit was apparent, he was of opinion that it would have been unjustifiable trifling with the disease to have given a longer trial to the treatment.

* Trans. of Lond. Pharm., p. 537.

Lect. on the Venereal Disease, Lancet, 1848.

Cyc. Pract. Med., vol. i. § Lancet, Nov. 30, Dec. 7, and Dec. 14, 1861.

2564. In Debility resulting from Prolonged Lactation, in some forms of Dyspepsia, in Anmia and Leucocythmia, in Catarrhal and Leucorrhal Discharges, in Myalgia and Muscular Pains simulating Inflammation, Mr. Taylor resorted to the Hypophosphites with more or less marked benefit; in fact, in all cases where there is reason to suppose the phosphates to be morbidly deficient, they may be prescribed with a good prospect of success. The demand for the Phosphate of Lime in the construction of the teeth contributes to the disturbing influence called the Fever of Dentition: in this also, whether it occurs in weakly, ill-fed children, or in the robust, Mr. Taylor employed them with marked success; in the former class he combines them with some tonic or aromatic tincture, in the latter with Acetate of Ammonia or Syrup of Rhubarb. Mr. Taylor's suggestive paper will well repay careful perusal.