Iodide or Ioduret of Antimony. Antimonii Oxy-iodidum. Oxy-iodide of Antimony.

Med. Prop. and Action. Alterative and diaphoretic. Dr. Vanden Corput,* of Brussels, from an examination of these preparations, concludes that the Oxy-iodide is the only chemical form in which the combination of Iodine and Antimony can be conveniently used as an internal remedy; the Iodide becoming too readily decomposed by contact with the liquids of the digestive canal. The Oxy-iodide is a drug of great efficacy, being at the same time an expectorant and a powerful alterative. In doses of from 5 to 25 centigrammes (from about gr 2/3 to gr. iij 1/2., it frequently excites nausea, and sometimes vomiting; at other times it produces frequent and copious stools. The effects may be easily modified by opiates or some other narcotic agent capable of deadening the susceptibility of the stomach. Tolerance appears to be easily established, the dose being gradually increased from 20 to 50, or even to 70 centigrammes (from about gr. ij 3/4. to gr. vij., or even to gr. x.), in twenty-four hours. These doses excite primarily much diaphoresis, which is soon followed by considerable depression of the circulation. The numberof inspirations is diminished in frequency, and this effect is accompanied by extreme muscular weakness. The Iodide externally applied, in the form of ointment or plaster, is a powerful revulsive, analogous in its action to Tartar Emetic. Like it, it creates a pustular eruption, but it has this advantage, that independent of its local derivative action, it operates beside on the organism in a general manner, by giving up a part of its iodine, which is then either directly absorbed, or, by being vaporized by the heat of the body, surrounds the patient with an iodized atmosphere.

Dose of the Oxy-iodide of Antimony, as an alterative and diaphoretic, gr. 1/6 gradually increased to gr j., or even more, if tolerance be established.

296. Therapeutic Uses

The Oxy-iodide is particularly serviceable in Inflammation of the parenchyma of the Lungs, and especially in the second stage of Pneumonia, also in the treatment of Subacute Bronchitis and of (Edema of the Lungs. Its alterative and diaphoretic properties are also manifest in the treatment of Rheumatic Affections, as well as in certain Inflammatory Diseases of the Heart. The Iodide, as an external application, proves advantageous in the same affection as Tartarized Antimony, but it should be borne in mind that its action is more powerful.