1. Syncope. When disease of the heart exists, the sudden abstraction of a large quantity of blood has been followed by fatal syncope, from the pressure of the effused fluid on the surface of the heart being subjected to sudden and great diminution. 2. AnAemia. This is principally to be dreaded in women, and persons of debilitated constitutions, whose vital powers are insufficient to replace the red globules of the blood, and restore it to its normal condition. 3. Disease of the heart. Repeated large bleedings have been shown to produce this effect. 4. Excessive hAemorrhage. 5. Dropsy; this is rare. 6. An increased susceptibility of the surface of the body to the influence of cold, and, therefore, the liability to relapse, or to the excitement of fresh inflammatory disease. (Alison.*) 7. Polypus of the heart. Dr. Hope states that he has distinctly observed this sequence, when blood-letting has been extensively employed in organic disease of the heart.