In Small-pox, the local application of the Nitrate to the pustules has been proposed as a means of arresting the disease in the vesicular or papular stage, and also of preventing subsequent "pitting" or cicatrization. This treatment has been particularly recommended by Velpeau, Bretonneau, and Serres. * The apex of the pustule is directed to be removed, and a sharp pencil of the Nitrate to be inserted into each; but the process is tedious, painful, and, as has been shown by Girardin, not without danger. A solution of the Nitrate (gr. xx. - Aq. fj.) has been successfully substituted; it is to be applied lightly over the surface by means of a camel's-hair brush. Dr. Rowland prefers a stronger solution (3j. ad Aq. fj.), and speaks highly of its efficacy. He regards a weaker solution as irritating and insufficient. Mr. Higginbottom recommends a still stronger solution (iv. - Aq. Dest. f3iv.). It is not necessary to puncture the pustules. The solution should be applied on the fourth or fifth day of the eruption. As a gargle to the throat in small-pox, he uses a solution of Arg. Nit. j. ad. Aq. Dest. fiij.

* Med. Times and Gaz., Jan. 2, 1864, p. 46, and Jan. 16, 1864, p. 75.

Med. Times, Dee. 28,1850.

Trans, of Med. Soc. of New York, 1865, p. 238, and Brit, and For. Med. Chir. Rev. 1856, p. 250.

§ On Diphtheria, 1859.

|| Op. cit.

¶ Dublin Journ. Jan. 1839. ** Library of Medicine, vol. iv. p. 3i Ibid., vol. iv. p. 37.

350. In Herpes Zoster, Or Shingles, A Similar Mode Of Treatment Is Recommended By Mr

Erasmus Wilson. § He states that it acts beneficially, and brings the cure more speedily to a termination than if left to itself.

351. In Erysipelas, the Nitrate of Silver, as a local application, was first proposed by Mr. Higginbottom,|| as a means of arresting the progress of the inflammation. To effect this, it is necessary that the Nitrate should be so applied as entirely to encircle the inflamed part. Previous to its use, the surrounding skin should be well washed, and afterwards dried; the Nitrate may then be applied, care being taken that no interstices are left, through which the inflammation may pass and extend itself. This measure is often effectual, but, it must be confessed, occasionally fails - probably in a great measure from the careless manner in which it is applied, and the neglect of proper caution Another form of application also proposed by Mr. Higginbottom, is to pencil the whole of the inflamed surface with the Nitrate, either in substance or in solution, so as to cause a slight amount of discoloration. The parts are then to be exposed to the air and kept cool. The Tincture of Iodine has been found more effectual by Dr. Davies,¶ of Hertford, Dr. Pereira,** and others.

352. In Pemphigus, After The Bullae Have Burst, And Excoriations Remain, Mr

E. Wilson found that the best application to promote a cure was a solution of the Nitrate of Silver (gr. ij. ad Aq. fj.). In Molluscum Simplex, he advises touching the tumours with the solid Nitrate; and, in some instances, he opens the tumour with a lancet, and applies the Nitrate to the interior. Erythema Infantum is greatly benefited by being pencilled with a weak solution of the Nitrate (gr. i. - ij. ad Aq. fj.). In Frambcesia, or Yaws, Mr. Mason* derived great benefit from the direct application of the Nitrate to the tubercles; and in one recent case, this treatment being continued for a few months, the papulae disappeared, and no other tubercular yaws were formed.

* Archiv. Gen. de Med. vol. viii. Med. Times and Gaz., Dec. 13,1856. Med. Times and Gaz., July 11, 1S63, p. 54. § On Diseases of the Skin, p. 210.

|| On the Uses of the Nitrate of Silver, Ed. 2, 1829. ¶ Selections in Pathology, 1839. ** Mat. Med. vol. i. p. 968. Op. cit. p. 192.