Oxide of Silver. Ag. O. Called also Argentum Oxydatum Euscum and Argenti Protoxidum. Is a compound of Silver 93.103, Oxygen 6.897, in 100 parts; or 1 Eq. Silver = 108 + 1, Oxygen = 8 = 116, Eq. Wt.

Med. Prop. and Action. Tonic, sedative, and anti-spasmodic, in doses of from gr. 1/2 to gr. ij. Its medical properties are very similar to those of the Nitrate, over which it has the advantages of being milder in its operation, and of not so readily causing discoloration of the skin Its administration, however, cannot he continued more than five or six weeks with safety. Its local effects are slight compared with those of the Nitrate. It is a mild astringent and slight caustic. Its internal administration occasionally induces salivation. Dr. Thweatt § considers that its action is specifically directed to the uterine system. It is contra-indicated in all inflammatory states, in plethora, and in sthenic diseases generally. The rules given for the administration of the Nitrate apply, with equal force, to this salt. As a tonic and astringent, it has been advised by Drs. Clendenning, Golding Bird, and Sir J. Eyre. Externally, it may be employed in the form of ointment (gr. lx. of the Oxide to oz. j. of Lard). Under its use, the stools assume a black colour. When the Oxide is united with certain organic substances, the silver becomes reduced. It is entirely incompatible with creosote. When mixed together, the creasote becomes oxidized, and great heat and even flame may be produced. This should be remembered in prescribing the Oxide in stomach affections.

* Lancet, Oct. 5,1861.

Giornale de Ziscia, vol. xi.

Dr. Butler Lane, Lancet, Feb. 6, 1841, And Med. Chir. Review, July 1840. § Amer. Journ. of Med. Sciences, July, 1849 (R).

Dose, gr. 1/2 - gr. ij. twice or thrice a day in form of pill

373. Therapeutic Uses

In atonic HAemorrhages, particularly from the Lungs and Stomach, Sir J. Eyre* employed the Oxide of Silver, in doses of from gr. 1/2 to gr. j. thrice daily. He speaks highly of its efficacy. It is inadmissible when inflammation is present.

374. In Menorrhagia, occurring in relaxed habits and debilitated constitutions, the Oxide of Silver appears to exercise a very powerful influence. In 30 cases of Menorrhagia in which Sir J. Eyre employed this salt, complete recovery attended its use in each. In no instance, he states, was its use followed by that blueness of the skin which so commonly attends a prolonged use of the Nitrate. He deprecates its use in larger doses than three grains daily. Dr. Butler Lane also testifies to its value, and Dr. Thweatt considers the Oxide of Silver to be in Menorrhagia, what Mercury is in Syphilis, and Quinine in Intermittents.

375. In Gastralgia, Gastrodynia, and in those forms of Dyspepsia attended with irritable stomach, and pain in that viscus after taking food, Dr. Golding Bird considers the Oxide as a highly valuable sedative and tonic. In these cases, he considers that it possesses all the good qualities of the Nitrate, without its inconveniences.

376. In Pyrosis, Sir J

Eyre found the Oxide particularly serviceable. In 10 cases in which he employed it, it was productive of manifest benefit. He gave it in doses of gr. 1/2 thrice daily. Strict attention to the bowels at the same time is necessary.

377. In Gonorrhoea And Gleet, It Has Been Successfully Employed By Dr

Lane. He relates several cases much benefited or cured, by the introduction into the urethra of a bougie smeared with the Oxide ointment (gr. v. - x., Lard 5j.). It should not be used to the exclusion of other remedies. It was also found very serviceable in Leucorrha, administered internally.

378. To Syphilitic Ulcerations,

Dr. Lane states that he has constantly used an ointment of the Oxide (gr. v. - x., Lard 3j.), and that he has generally found it answer better than any other local application. In Ulceration of the Cornea, with thickening and congestion of the eyelids, and in some forms of Ophthalmia, an ointment (Oxide 3j., 01. OlivAe fj.), applied with a camel's-hair pencil, is said to prove highly beneficial.

* Remarks on some Exhausting Diseases, 8vo. Lond. 1845.

Quoted by Dr. Lane, op. cit.

379. Against Tnia or Tape- Worm, the Oxide appears to act in some degree as an expellant. Dr. Whittel* relates two cases, in which the exhibition of this salt, in doses of gr. i. - ij. was followed by the expulsion of TAenia. It was given in combination with Potass. Bitartras.