In carcinoma of the Uterus, in Irri-table Uterus, and in several cases of Menorrhagia, Arsenic has been used with decided benefit by Mr. Hunt,§ of Dartmouth. Its value in atonic Menorrhagia is confirmed by Dr. Locock,|| who states that he has employed it with great success in this and many other uterine affections. He considers that it acts specifically. In one case of Cancer of the Uterus, in which no relief was obtained from 24 grains of Morphia, great ease and benefit accrued from small doses of Liq. Arsenicalis. Dr. Locock, who quotes this case, thinks highly of the value of Arsenic in this class of diseases. Mr. Hunt advises it, in doses of gr. 1/20, thrice daily, immediately after meals. In Menorrhagia, Leucorrha, and Uterine Hmorrhage in threatened Abortion and after Delivery, Dr. A. Burns* speaks of Arsenic as a most reliable remedy. He prescribes, in HAemorrhage, at first ex. - xx. of Fowler's Solution, according to the severity of the case, and repeats ex. every fifteen or twenty minutes, till the discharge ceases. In Leucorrha he gives ev. thrice daily till a cure is effected.
* Dict, of Pract. Med., art. Cancer, vol. i. p. 237.
Mr. Lane, Med. Chir. Trans, vol. viii. p. 201.
Med. Chir. Trans. vol. ii. p. 393. § Medieo-Chir. Trans. vol. xxi. Art. 5.
|| Lancet, April 14, 1838.
He directs a sheet of white paper to be dipped into a solution, composed of 1 part of Arseniate of Soda and 30 of water. The paper is then made into little cigars, and the patient is directed to smoke one or two daily, in such a manner that the fumes may pass into the lungs. This is accomplished by inspiring at the moment the fumes enter the mouth. At first, it causes slight irritation; but after a short time, the cough and expectoration diminish. Of eight cases in which it was tried, four were decidedly relieved, and in four it failed to afford relief. Arsenious fumigations in Phthisis were advised by Dioscorides. Dr. Leared tried Arsenic conjoined with Cod Liver Oil and Sedatives in nine cases of Phthisis, and from these he draws the conclusion that it would prove useful in Phthisis by virtue of its action on the respiratory system as well as by its tonic properties, but that it is not easily borne by the digestive system, even when combined with sedatives.
421. In Plethora, with determination of blood to the head, Arsenic is reported to have been used with great advantage. || In Apoplectic Congestions, the use of Arsenic is advocated by Dr. Lamare Piquot,¶ who considers that it acts by reducing in a remarkable manner the excess of the red globules of the blood, which in these cases he supposes to exist in a morbid and dangerous degree. Its use is confined to strong plethoric subjects, and is not applicable to weakly old subjects when there is a disposition to apoplectic congestion. He prescribes Arsenious Acid in doses of gr. 1/15gr. 1/6, in a fiv. mixture daily, one half at each meal. In one case of this description, I witnessed more relief from the use of Liq. Arsenicalis, in combination with Liquor PotassAe, than from the local abstraction of blood, blisters, and setons.
* Amer. Journ. of Med. Sci, Oct. 1859.
Brit, and For. Med. Rev., Feb. 1841.
Med. Times and Gaz., Jan.28,1863.
§ Rev. Med. Chir. 1848.
|| Edin. Med. and Surg. Journ. April, 1839. ¶ Gaz. Hebdom. de Med., Jan. 20, 1S60.
Mackenzie* states that he has seen Arsenic most serviceable, particularly when it partakes more of a catarrhal than an asthmatic character. Where the disease has been slight, or the medicine has been given with a view of improving the tone of the mucous membrane, rather than of correcting morbid action, doses of eiij. of Liq. Arsenicalis, or even less, are preferable; whilst, on the other hand, if the irritation has been excessive, or resists these, larger doses may be given, and their action modified or assisted, in different cases, by remedies of a kindred character.
Mackenzie found Arsenic productive of the best effects, but more especially in those cases in which the affection was of a local character, and there was an absence of inflammatory action, as well as of febrile disturbance. These states contra-indicate its use.
424. In Catarrhal Ophthalmia, and more especially in those forms which are of a passive, subacute, or chronic character, or where the irritability of the conjunctiva is excessive, Arsenic has proved very beneficial in the hands of Dr. Mackenzie. In Strumous Ophthalmia, Dr. Thorp states that Arsenic is a most valuable agent in inveterate cases, more especially when complicated with chronic eruptions of the scalp or cutaneous surface generally.