Bebeerine. Alkali of Bebeeru Bark derived from Nectandra RodiAei, or Greenheart Tree, a native of British Guiana, called by the Indians, Bibeera; by the Dutch colonists, Sipeeri. Chem. Form. C38 H21 NO6.
Beberia Sulphas. C38 H21 NO6, HO, SO3. Sulphate of Beberia has been advised as a cheap substitute for Quinine. The following is a convenient form for its exhibition as a tonic: - Sulphate of Beberia gr. xxx., dilute Sulphuric Acid exxv.. Syrup fl. oz. j., Tincture of Orange Peel fl. oz. j., Water fl. oz. iv. Dose, a tablespoonful thrice daily. (Pereira.)
* Med. Gaz., Aug. 22, 1S51.
Bull. Gen. de Therap., Sept. 1840.
§ Revue Medicale, April 1840. || Edin. Med. Journ., April 1862.
Med. Prop. and Action. Sulphate of Beberia is tonic and anti-periodic. Its superiority over Quinine is stated to be, 1, its cheapness; and 2, its not producing headache and cerebral disturbance; and it is, consequently, preferable in plethoric subjects. It is also found to cause less gastric and vascular excitement. Warburg's Drops are said to contain a considerable portion of this alkali (Royle). Its intensely bitter taste is an objection to its use. It is officinal in the British Pharmacopia.
Dose of Sulphate of Beberia. As a tonic, gr. j. - v.; as an anti periodic, gr. v. - x. thrice daily.
In Intermittent and Remittent Fevers, Dr. Maclagan,* to whom we are indebted for the introduction of this remedy, relates 40 cases of Remittent and Intermittent Fevers, treated by Bebeerine. In 34, a complete cure was effected; in the other 6, it failed. Since that period (1843), it has been extensively employed in the East and West Indies, America, &c, and, from the strong evidence adduced in its favour, we may conclude that, next to Quinine, it is one of the most efficacious remedies we possess. I cannot speak of its merits or demerits from personal experience. It is stated to be particularly serviceable where cerebral disturbance is present. Dr. Maclagan directs it to be taken in doses of gr. iij. - iv. every 3 or 4 hours, so that gr. xx. is taken before the expected paroxysm. In the treatment of these fevers in India, it has been successfully employed by Drs. Godfrey, Dorward, Anderson, Falconer, Dempster, &c.; still it does not seem to have maintained its early reputation as an anti-periodic. Dr. Garrod states that, in three cases of intermittent fever in which he tried it, it signally failed in arresting the progress of the disease. The same patients were cured by ordinary doses of quinine.
Maclagan* found it eminently successful, even in cases in which Quinine had previously failed. He records instances in which the benefit derived was most unequivocal. In some cases, one dose of gr. x. night and morning, is preferable to several small ones. Its efficacy in this class of cases is attested by Prof. Simpson, of Edinburgh, Dr. Mac-farlane, and others.
H. L. Williams § states that he has found the Sulphate of Bebeerine equally efficacious with Quinine. In one case, which he publishes at length, it effected a cure in three weeks. The dose employed was gr. ij. night and morning. Blisters, purgatives, and astringent collyria, were simultaneously employed.
Belladonna. See Atropa Belladonna.
* Edinburgh Med. Surg. Journ. No. 103, 1843; and April 1, 1845, p. 359. Med.Times and Gaz., Feb 13, I8ti4.
Edin. Med. Surg. Journ., loc. cit. § Med. Times, Mov. 4, 1848