The seeds of Simaba Cedron, a tree. Nat. Ord. Simarubiaceae. Indigenous to New Grenada and Central America.

Med. Prop. and Action. The intense bitterness of Cedron indicates its tonic quality. Amongst the natives of South America it has long been held in high repute as an antidote to Snake Sites, as a preventive of Hydrophobia, and as a remedy in Intermittent Fevers, Dyspepsia, Spasm of the Bowels, &c.

779. Therapeutic Uses

Snake Bites. Trials with it by Drs. Carentre,* Herran,+ and others seem to confirm the statements with regard to its efficacy as a remedy in Snake Bites. The mode of administration by the natives is to give grs. ij. - v. of the seed in a wine-glassful of spirits or warm water, and to repeat this every second hour until relief is obtained. A weak infusion is also given to allay thirst. At the same time the wound is washed with an infusion of the seeds, and covered with scrapings of the seed in the form of cataplasm secured in situ by a bandage. Dr. Herran, in the eight cases in which he tried it, gave gr. v. - vj. in a spoonful of brandy, and dressed the bite with the Tincture.

780. Intermittent Fevers

With regard to its use in intermit-tents, it has been favourably reported of by M. Rayer and by Dr. Purple, § of New York; whilst M. Lelut|| expresses himself doubtful as to its value in this class of diseases. Dr. Purple regards it as possessed of decided anti-periodic virtues, in many respects equal to Quinine. He considers that its marked tonic properties entitle it to a prominent place in the Materia Medica.

* Amer. Journ. of Med. 8ci., Jan. 1851. Ann. de The'rap , 1851, p. 59. Ibid, 1852, p. 161.

§ New York Journ. of Med., Sept. 1854.

|| Ann. de The'rap., 1853, p. 223 (Note).

781. Other Diseases

Dr. Guier* employed it successfully in Cholera Morbus, Colic, and Neuralgia of the Face, and Dr. B. Thompsonf derived benefit from it in Gout. The dose appears to be somewhat uncertain; the ordinary doses are gr. ij. - vj., but Dr. Purple considers these as far too small; he prescribed gr. x. - xxx. every four hours, and he states that though in very large doses it may produce griping and diarrhoea, yet that these effects are easily controlled. This is hardly in accordance with the statement of Dr. Rotellini, who affirms that it is poisonous in overdoses, and that 25 or 30 grains have proved fatal. It may be given in the form of Acetous Tincture (gr. xl., Acet. Dest. fl. oz. j.) in doses of exx. - xxx.