Cinchonine. An alkaloid found chiefly in the pale varieties of Cinchona. Chem. Form. C40H24N2O2. In the form of the Sulphate (C40H24N2O2HO,SO3 + 2 HO) its action is similar to that of Quinine; but it is less energetic, and consequently requires to be given in larger doses: it is, however, occasionally substituted for it. The Hydrochlo-rate of Cinchonine has also lately come into use. Med. Prop. and Action. Tonic and anti-periodic. Dose of the Sulphate of Cinchonine, gr. j. - gr. x., or more. Dose of the Hydrochlorate of Cinchonine, gr. j. - gr. x.

872. Therapeutic Uses

In Intermittent Fevers much has been written on the anti-periodic powers of this agent. The recent researches of Dr. Moutard-Martin* have served to place its character in its true light. He deduces from extensive experience the following conclusions: - 1. Sulphate of Cinchonia, administered for Intermittent Fever, has an unquestionable but variable action. 2. Sometimes its action is rapid, and it arrests the paroxysms like Quinine; at other times it is slow, whatever the dose exhibited, and the paroxysms cease gradually. 3. The dose must always be larger, at least by one-third, than that of Quinine. 4. To obtain its curative action, a dose, ranging from gr. x. to gr. xv., must be used according to circumstances. 5. At this dose it sometimes induces certain physiological effects which it would not be prudent to exaggerate. 6. Its therapeutic action is not in proportion to its physiological effects, for it sometimes cures without the latter being manifested; on the other hand, the physiological effects may be energetic, and yet it may fail to cure. 7. It cannot replace Quinine in severe intermittents. 8. It may become a valuable adjunct to Quinine, in completing a cure commenced by the latter. This combination would secure certainty of treatment with economy. Testimony to the value of the Hydrochlorate of Cinchonine in the treatment of ague has lately been borne by Mr. ('. G. Taylor.* Dr. Garrod states that he has had abundant evidence that peculiar effects often result from Cinchonia Salts, which are not produced by the same amount of the corresponding Salts of Quinine.

* Medical Circular, 1860.

873. In Neuralgia, It Was Found By Dr

Pepper to succeed when Quinine had failed. In Gastralgia it proved successful in the hands of Dr. Franchini, who found it serviceable also in hysterical nervous affections. In Conditions of Debility it is largely prescribed in some of the London hospitals as a substitute for Quinine.