Codeine (C36H21NO6 + 2 HO), an Alkaloid, was discovered by Robiquet in Opium in 1832. It is soluble in boiling water, Alcohol, and Ether, but not in alkaline solutions. It unites with Acids, forming crystallized salts.
* Synopsis of Diseases of the Skin, 2nd Ed.
Lectures, p. 400.
Pharm. Journ., March 1844.
§ Ranking's Abstract, vol. xiv., 1851, p. 204.
|| See Haller in Disput. ad Morbos, vi.
Med. Prop. and Action. Sedative and narcotic, ranked by M. Aran first amongst remedies of this kind. Inferior to Morphia, he remarks, for calming pains, for this reason only that it must be given in larger doses; superior, inasmuch as it never occasions a heavy agitated sleep, does not bring on perspirations or eruptions of the skin, does not derange digestion, nor induce constipation nor vomiting. As a means of procuring calm and refreshing sleep it is very valuable. Dr. Garrod, on the contrary, states that he has found gr. v. of Codeia fail to relieve pain, which was readily subdued by gr. 1/4 of Morphia. He considers that the therapeutics of Codeia require to be investigated. Dr. Aran speaks highly of the relief obtained from it in the Coughs of Bronchitis and Phthisis, in Rheumatism, Gout, Cancer, dc.
Dose, gr. 1/2, gradually increased to gr. ij , or more.