Creasote, or Kreasote. C16H10O2. A Product of the Distillation of Wood Tar. It is formed during the preparation of Pyroligneous Acid by the destructive distillation of Wood. It is also obtained from Oil of Tar, and is contained in Wood Smoke. It is closely related to Carbolic (Phenic) Acid. Sp. Gr. 1.065.
Med. Prop. and Action. Stimulant, sedative, rubefacient, and antiseptic. It possesses the property of immediately coagulating albumen; and to this may be ascribed many of its effects on the living system, and its power of preserving for months, meat which has been saturated with it. When added to blood, the latter thickens and becomes reddish brown, with small white spots, probably coagulated albumen; on further exposure to the air, the blood acquires a yellowish red colour. When applied to the tongue, Creasote causes violent pain, but without redness or tumefaction; a strong taste of smoke extends to the throat, and there is a copious flow of saliva. Taken internally in small doses, it occasions a sensation of warmth in the stomach, expels flatus, with eructations smelling strongly of Creasote, and appears to exercise a peculiarly sedative action on the stomach, allaying nausea and vomiting more certainly than most other medicines. It increases the flow of urine, to which it communicates its odour. In over-doses it produces the following symptoms, as observed by Mr. Macnamara:* - profound stupor, from which the patient could only be roused for a minute; the countenance flushed, and fuller than natural; the eyes fixed, but the pupils neither dilated nor contracted; the pulse slow and laboured; the heart's action remarkably slow and weak; the stomach irritable, and the ejecta bore a strong smell of Creasote. When aroused, vertigo and uneasiness in the head were complained of; and also a burning pain along the oesophageal track, and in the stomach. Stimulants, the cold douche, and mustard emetics relieved the patient. Applied pure to a bleeding surface, Creasote is styptic.
Offic. Prep. 1. Mistura Creasoti (Creasote exvj.; Glacial Acetic Acid exvj.; Spirit of Juniper fl. drm. ss.; Syrupfl. oz. j.; Distilled Water fl. oz. xv.). Dose, fl. oz. ss. - fl. oz. iss. 2. Unguentum Creasoti (Creasote fl. drm. j.; Simple Ointment oz. j.).
Dose of Creasote, ej. - ev. in pill, or rubbed up with a few drops of Acetic Acid and Mucilage in Aromatic Water. If given in mixture, it should be well diluted: 1/2 fl. oz. of fluid to 1 drop of Creasote.
Post-mortem appearances of animals killed with Creasote. All the tissues of the body, except the liver, exhaled a strong odour of Creasote; the mucous intestinal membrane inflamed throughout. In the heart and great vessels the blood was coagulated, the lungs were greatly congested, the brain natural. Death is probably caused mechanically, the Creasote coagulating the albumen of the blood, and preventing its circulation through the arterial system.
Incompatibles. The strong mineral acids; all solutions containing Albumen. It must not be prescribed in pill with Oxide of Silver, unless the latter be first mixed with liquorice powder; otherwise the mass will take fire.