7. It Is Also Advisable That The Patient Should Not Be Much Exposed To The Sun

In some instances exposure seems to have promoted or hastened the blue appearance of the skin.

8. The Course May Be Continued With Safety For A Month Or Six Weeks

Dr. J. Johnson says for three months

9. If discoloration of the skin occur, the remedies from which most benefit is derived are Iodine, Nitric Acid, and the Bitartrate of Potash.

10. Before commencing its use the pat ent should be made acquainted with the possible ill consequences which may result from it.

11. It may be admin stered in larger doses and for a longer period in the form of pill than in that of solution.

12. If, in the application of the solid Nitrate to the fauces, urethra, &c, a. piece be accidentally left in any of the passages where it cannot be extracted or where it causes great pain, a solution of common salt should be used as an injection.

13. When solutions are to be injected into any of the cavities, a glass syringe should be employed.

14. The local application of the Nitrate in solution to the eye, is sometimes followed by a blackish or bluish grey discoloration of the conjunctiva. It is usually described as "indelible," but it maybe partially or altogether removed by a weak solution of the Hyposulphite of Soda (gr. x. ad Aq. j.) - Dixon.

Incompatibles. Acids and Acidulous Salts; Alkalies and their Carbonates: Lime-water; Spring and River Water; Soaps; all solutions of Vegetable Astringents; Chlorides; Liq. Arsenicalis; Albumen, and Milk.

315. Therapeutic Uses

Diseases of the Abdominal Viscera. The value of the Nitrate of Silver in Dyspepsia was first established by the late Dr. James Johnson,* who relates many obstinate cases, attended by morbid sensibility and hypochondriasis, which yielded to its use. He considers that its probable action consists in lessening the sensibility of the nerves, and thereby rendering them insusceptible of irritation. He advises a formula similar to the following: -315 Therapeutic Uses 32 Argent. Nit. gr. 1/2, Ext. Hyoscyam. gr. ij. - iv., ft. pil. omni nocte sumend. The quantity of the Nitrate may be gradually increased to gr. ij. - iij. daily, and this may be continued with safety for six or eight weeks, but not beyond that time. Strict attention to the diet should be observed. In some cases, it may be advantageously combined with small doses of Quinine. Dr. Copland also bears witness to its efficacy. Dr. Fleming prefers administering it in solution (Argent. Nit. Crystal. gr.j. - iv. ad Aq. Destil. fss.) to be taken at bedtime on an empty stomach, and repeated every night, or every second, third, or fourth night, according to the severity of the disease. In very obstinate cases he introduces the solution into the stomach by means of an apparatus.

316. In Gastralgia, particularly when attended by sour vomiting or Pyrosis, the Nitrate of Silver has been successfully employed by Drs. J. Johnson,; Osborne,§ Boudin,|| Hudson,¶

* On the Influence of Tropical Climate, 6th Ed. p. 669. Med Times, Jan. 1859. Ot supra.

§ Dublin Journal, vol. viii. II Edin. Med. and Surg. Journ. No. 141. ¶ Dublin Journal, vol. xvii. p. 235.

Brigger, Steinitz, and Mr. Langston Parker. From the experience of these writers, there are few, if any, remedies which exercise a more powerful and beneficial influence. It may be given in doses of gr. 1/3 to 1/2 twice or thrice daily, in combination with Ext. Taraxaci. Dr. Symonds,* in bearing testimony to its efficacy, states that he has found it chiefly useful in those cases which present a combination of nervous irritability with chronic or passive congestion of the stomach. In Pyrosis he found it most successful in doses of gr. j. thrice daily. In Chronic Gastritis of the worst kind, Professor Wood states that this is the most effectual remedy he knows of. Dr. Fleming advises that in these cases the crystallized Nitrate dissolved in distilled water be injected into the stomach.

317. In Obstinate Diarrhoea of Children, when the Acetate of Lead and other astringents have failed in arresting the discharge, the Nitrate of Silver often proves effectual. Dr. Willshire§ observes on this point, " I know nothing like Argenti Nitras for stopping the diarrhoea, even if it does no more than this; but I think that it does far more. It appears to me to alter the general assimilative functions." He advises the following formula: -

315 Therapeutic Uses 33 Argent Nit. gr.j., Acid Nitric Dil. ev., Mucilag. Acac, Syr. Simp. aa f3vj., M. sumat f3j. 4ta quaque hora. It may be given safely to children of a year old. The French physicians employ it largely, not only by mouth, but in the form of enema. M. Trousseau advises from gr. 1/6 to gr. ij. to be dissolved in fx. of fluid, and to be thrown high up into the intestine, having previously employed an enema of common salt. In mild cases he recommends one injection daily for three or four days; but in bad cases it may be repeated twice in twenty-four hours.