Cooper, and in the practice of others it has occasionally been useful; but the treatment is not devoid of danger, and it will often prove ineffectual. A large blister to the loins aids its internal exhibition.
In Albuminuria, T. Cantharidis has been successfully employed by M. Monneret. He commences with small doses, and gradually increases it to 60 drops. In the majority of cases its use was attended with decided benefit. Raver also speaks favourably of it, but considers that it is an uncertain remedy, and one which may prove dangerous in the hands of the inexperienced. In five cases treated with it by Dr. Wells, there was marked improvement in three, and in two it failed. Dr. Wells observed that it sometimes increased the coagulability of the urine. In Granular Disease of the Kidney, the Tincture (eiv. - xij.) is favourably mentioned by Rayer and Dr. Copland.
Watson} recommends the T. Cantharidis. It certainly has, he observes, sometimes a very beneficial effect. Generally when it does good, it acts as a diuretic; and Dr. Seymour suggests, that it is most likely to be useful in cases of serous effusions into the spinal cavity, or Spinal Dropsy. He recommends the Tincture as a good diuretic; and supposes that it benefits Paraplegia by tending to produce absorption of the serum effused within the vertebral canal.
Beatty, is stated by Dr. Graves|| to be very efficacious in many instances: - Infus. Cinchon. Co. fvj., T. Canthar., T. Opii aa fss., M. sumat. coch. min. aut mag. ter in die. A similar formula was found very successful by Dr. Lettsom.
Irven¶ strongly recommends T. Cantharidis. He commences with from 10 to 20 drops thrice daily, and gradually increases the dose until the patient takes 80 drops daily. Under its use he observed decided improvement.
702. In Deafness depending upon a thickened state of the membrana tympani, and where there is much irritation of the meatus externus, Mr. Toynbee** states, that he has seen great benefit follow the application of an ointment composed of 3ss. of Powdered Cantharides and j. of Lard. It should be applied below and behind the ear twice daily; at the same time he advises alterative doses of Blue Pill, or some other mercurial.
* St. Thomas's Hogp. Rep., No. iv. Gaz. des Hopitaux, Oct. 13, 1842. Med. Chir. Rev., No. lxx. p. 467. § Lectures, vol. i. p. 547.
|| Dub. Journ. of Med. Sciences, No. iv. ¶ Lancet, Dec. SO, 1S42. ** Monthly Journal, March 1849.
703. In Lepra and Psoriasis, the internal exhibition of Cantharides has been in common use since the time of Dr. Mead,* in 1767. He used it with success, and others have found it occasionally beneficial. Cantharides, observes Dr. Schedel, seems more useful when Psoriasis appears without evident cause, when it occurs among subjects of a soft and flabby constitution, when the eruption is very extensive, and when a course of purgatives has been had recourse to without advantage. The dietetic regimen should be severe. He advises the Tincture in doses of gutt. iij. - v. thrice daily, and the daily dose to be increased gutt, v. every six or eight days. It should be immediately discontinued if it disagree. Given thus, Dr. Schedel states that he has seen the greatest benefit from its use. In Eczema, its internal use with equal parts of T. Camph. cum Op. is advised by Mr. E. Wilson.
T. Cantharid. f3j., Liniment. Sapon. f3vj., M. nocte maneque applicand.