Graves* states that he has occasionally derived remarkable benefit from the use of Nitric Acid, given in sufficient doses. He considers that it possesses the advantage of combining tonic with aperient qualities.
1897. In Chronic Affections of the Spleen, in addition to the employment of tonics and purgatives, Annesley recommends the internal use of Nitric Acid as advised in section 1894, together with the daily use of the Nitro-muriatic lotion over the region of the spleen and liver. Many chronic cases in old Indians are much benefited by this treatment.
Bardsley observes that Nitric Acid, diluted with water (f3iij. ad Aq. Oiij.), is generally productive of benefit, mitigating the thirst and heat, and diminishing the quantity of the urinary secretion. In the majority of cases, it may be taken with advantage; but it is inadmissible if diarrha be present.
. 1901. In Chronic Rheumatism, where the constitution has been debilitated by Mercury, or repeated attacks of Syphilis, dilute Nitric Acid (ex.) in combination with Sarsaparilla and with Dover's Powder, at night, has been found productive of the best effects.
1903. In Hospital Gangrene, and Phagedenic Ulcerations, the local application of strong Nitric Acid was first advised by Mr. Wellbank,|| who gives the following directions for its use: - Having thoroughly cleansed and dried the ulcer, the surrounding parts should be covered with a thick layer of lard or ointment, to prevent the acid coming in contact with them. A pledget of lint, fastened to the end of a stick, is to be saturated with the acid, and to be carefully pressed on every part of the nulcer, till it is converted into a firm dry mass. After the first pain, which is generally severe, has subsided, the previous sufferings will be greatly relieved. Cold-water dressings are to be applied. The eschar formed by the acid is to be removed in twenty-four hours, and a common stimulating ointment or lotion applied. Should the phagedenic character of the ulcer reappear, it will be necessary to repeat the application of the acid. This, without doubt, is the best and most certain treatment of phagedenic ulceration. The constitutional treatment must be regulated according to the state of the patient. Mercury in every form should be avoided. To sloughing and ill-conditioned Ulcers, Sir A. Cooper* advises Nitric Acid largely diluted (el. - lx. ad Aq. Oj.).
* Clin. Lect., vol. li. p. 215.
Essay on the Venereal Disease.
Cyc. Pract. Med., vol. i p. 548.
§ Mb. of Med., vol i. p. 363.
|| Med.-Chir. Trans., vol xi p. 369.
1904. In Cancrum Oris, the late Samuel Cooper found the strong Nitric Acid most efficacious in the worst forms of this disease. The constitution must at the same time be supported, and Quinine administered.