iij.; Refined 8ugar grs. xxx.; Prepared Lard and White Wax of each q. s. Divide into twelve cones; each cone to be dipped in a mixture of three parts of Wax and eight of Lard melted together). Each suppository contains a quarter of a grain of Hydrochlorate of Morphia.
xx.; Tincture of Tolu fl. oz. ss.; Refined Sugar in powder oz. xxiv.; Powdered Gum Arabic oz. j; Mucilage of Gum Arabic fl. oz. ij. or q. s.; Boiling Distilled Water fl. oz. ss. Divide into 720 lozenges). Each lozenge contains one thirty-sixth of a grain of Hydrochlorate of Morphia.
4. Trochisci MorphiAe et Ipecacuanhas (the same ingredients as Trochisci Morphias, with the addition of grs. lx. of Ipecacuanha. Divide into 720 lozenges). Each lozenge contains one thirty-sixth of a grain of Morphia and one-twelfth of a grain of Ipecacuanha.
* Cyc. Pract. Med., vol. iii.
A solution of Bimeconate of Morphia has been introduced into medicine by-Mr. Squire. It is of the same strength as Tincture of Opium. It is said to produce less cerebral disturbance and less constipation than other preparations of Opium. (See Opium).
Dose of the Morphia Salts, gr. 1/8 - 1/4 - 1/2, up to gr. j. For hypodermic injection, exv. - exxx. of a watery solution of the Sulphate or Acetate, containing gr. iv. to the fl. oz. This plan of administration should be employed cautiously, and the patient carefully watched.
Therapeutic Uses. Similar to Opium, for which it may be substituted in proportionate doses.
1804. In Tic Douloureux and other Neuralgic Affections, the en dermic application of Morphia occasionally affords great relief. Over the surface, denuded by a blister, the Morphia (gr. ss. - gr. j.) should be sprinkled; and if relief is not obtained in a few hours, it may be repeated. M. Bannieux* relates several cases in which its efficacy was unequivocal. Inoculation with Morphia over the affected part is advised by Dr. Brackett. By this means he cured an obstinate case of Sciatica. Scanzoni successfully treated Puerperal Convulsions by subcutaneous injections of Morphia, In Sciatica, the hypodermic method of introducing Morphia has been successfully employed by Dr. Levick § and others. It has been found by Dr. Henry Bennett |! of great use in relieving Uterine Pain. Dr. Bennett injects exxx. of a solution containing 4 1/2 grs. of Acetate of Morphia to the fL oz. The Liq. MorphiAe of the Pharm. is objectionable, as it contains spirit which is likely to produce inflammation. It does not seem to matter much in what region of the body the injection is made. Dr. Bennett chooses the precordial region for uterine and general pain, and for local neuralgia a spot as near the affected region as possible.
1805. In Chronic Deafness, Morphia, as advised in the last section, is sometimes effectual. Dr. Hobeke ¶ relates a case in which all other remedies had failed; he then applied a small buster behind each ear, and on the denuded surface sprinkled gr. ss. of MorphiAe Sulph. On the following day the deafness on the left side had ceased, and all the other symptoms were much relieved. In Inflammation of the Iris and Sclerotic, Mr. J. Z. Lawrence ** found Morphia produce a marked antiphlogistic effect. Its action apparently depends upon the known power of the remedy of reducing nervous irritability, which may be regarded as the primary cause of the inflammation.
1806. In Chronic Gastritis, Morphia is a valuable palliative, although generally inferior to Prussic Acid. Drs. Bardsley and Stokes advise it in doses of gr. 1/12 twice the first day, three times the second, and so on, increasing the quantity, until the patient consumes 1 or 1 1/2 grains in twenty-four hours. It was found particularly serviceable when there was an abundant secretion of mucus.
* Bull Gen. de Therap., t xxv. p. 17.
North-Westem Med. and Surg. Journ., Sept. 1851.
See Edin. Med. Journ., May 1860.
§ Med. Times and Gaz., July 18, 1863.
|| Lancet, March 12, 1864. ¶ Med.-Chir. Rev., No. lxxiv. ** Med. Times, Dec. 21, 1859; and Edin. Med. Journ., Dec. 1862.
Spasmodic Affections of the Bowels, the following treatment is stated to be very successful: - A blister is to be applied along the course of the spine, regulated as to size by the extent of the functions involved. To the denuded surface, Morphia in small quantities (gr. ss. - j.) is to be applied. Speedy relief is stated to follow the application. When the biliary secretion is evidently implicated, emetics and purgatives should be simultaneously employed.
Hope* recommends Morphia as a palliative. It should be given in doses of gr. ss. and persevered in for a considerable period.
For further therapeutic uses, see Opium.