O'Beirne,* Anderson, Earle, Curling, § and others; and although occasionally benefit, and even recovery, has resulted from their employment, yet they often fail to afford any amelioration of the symptoms. Such was the experience of Sir J. Macgrigor || during the Peninsular war. On this point, Dr. Todd¶ observes, that Tobacco is neither safe nor manageable; and adds, that he has seen more than one patient die, cured of Tetanus, under the use of this remedy. When employed, the strength should never exceed gr. xxx. of the leaves in Oss. of water; and great care is necessary to prevent too great an amount of depression by the administration of Ammonia, Brandy, and other stimulants. Dr. O'Reilly** has recorded a case of Poisoning by Strychnine which recovered under the use of Tobacco given in infusion: the total quantity taken in divided doses during twelve hours was gj. 3ij. A case of Tetanus recovered under the use of Nicotine is recorded by Mr. Tuffnell. Prof. Haughton, of Dublin, has also recorded two cases of traumatic and one of idiopathic Tetanus treated by Nicotine. Two of these cases recovered. The alkaloid had the effect of relaxing the muscles, causing a cessation of delirium, and producing profuse sweating, which exhaled a strong odour of snuff. The dose given was gutt. ss. to gutt. 2 1/2 in sherry and water; the dose being repeated several times in the day. One patient who recovered took 44 drops or 26.4 grs. in eleven days. The other took in all 54 drops = 32 1/2 grs. The patient who died was moribund when he began the medicine. Prof. Haughton remarks that Nicotine should be employed, and not infusion of Tobacco leaves, as in the latter the properties of the alkaloid are masked by two or more vegetable oils, the operation of which on the nervous system is unknown. Dr. John Ogle,§§ of St. George's Hospital, has since recorded a case of Traumatic Tetanus in which the Nicotine treatment was unsuccessful. Mr. H. J. Tyrrell || || has lately recommended the topical application of Tobacco in Tetanus. In Traumatic Tetanus, he applies a strong infusion of Cavendish Tobacco to the wound and surrounding parts, previously blistered. In the Idiopathic form, he recommends that the Tobacco should be applied to a blistered surface
* Dub. Hosp. Reports, vol. iii. Edin. Med.-Chir. Trans., vol. i p. 187.
Medico-Chir. Trans., vol. vi.
§ Treatise on Tetanus, 8vo, 1836.
|| Medico-Chir. Trans., vol. vi.
¶ Clin. Lect.,Med. Gaz., 1849, p. 766.
** Dub. Med. Press, June 23, 1858.
Ibid., Jan. 7. 1863.
Dub. Quart. Journ., xxxiv. p.172.
§§ Med. Times and Gaz., March 12, 1864.
|||| Med. Times and Gaz., Sept. 24, 1864.
over the spine. He has placed on record two cases successfully treated by this method.
In some, the ease it affords is remarkable; in others, it fails to produce any effect; whilst it sometimes appears to aggravate the symptoms. Experience in each individual case is the sole test of its utility.
1880. In Retention of Urine from Spasm of the Neck of the Bladder, a Tobacco enema is advised by Mr. Earle,* but it is greatly inferior to Opium.