1. Pregnancy. "Blisters," observes Dr. Dewees,* "are to be used with great caution with pregnant women; owing to the great excitability of their systems, they produce much pain during their operation, and this is not always followed by benefit." He states that, under these circumstances, he has seen entire retention of urine follow their use, and he thinks that, in two instances, they were the cause of premature labour. A case once fell under my own notice, in which abortion was apparently attributable to a blister applied to the throat for the relief of Aphonia. 2. Scurvy; here they are apt to produce gangrene. (Dr. Budd.) 3. The first stage of acute inflammation.