2332. In Phthisis, Cinchona Long Enjoyed The Reputation Of A Specific

This opinion was supported by Morton, Sedillot, and De Metternich, while by others it has been prescribed only to answer particular indications. Mead advises it before, and Heberden after, ulceration has taken place. Dickson limits it to haemoptysis; Fothergill to the latter stages of the disease; and Bayle seems to regard it solely as an anti-periodic. "From a variety of evidence," observes Dr. Cowan,* " it may be concluded that bark must be prescribed on the same general principles which indicate its administration in other chronic diseases, and that it has no claim to the character of a specific for Phthisis." In Louis's practice, Quinine was given in some cases where the rigors were very troublesome and regular in their recurrence; they yielded to the remedy, but the heat persisted, and the rigors also returned when the medicine was abandoned. The supposition that Quinine exerts any specific influence on the progress of Phthisis is now entirely abandoned. It is, however, commonly prescribed as a valuable tonic in that disease. It is generally given in doses of gr. j. - gr. ij. in combination with Sulphuric Acid and the Sulphate of Iron, or in the form of Citrate of Iron and Quinine. Cod Liver Oil may be administered at the same time.

* Translation of Louis on Phthisis, p. 377.

2333. In the advanced stages of Pneumonia and Pleurisy, when the patient is old, the constitution debilitated, and the case assumes a typhoid character, the Sulphate of Quinine, in combination with Sulphuric Acid, may be given with great advantage. In Gangrene of the Lungs, even when accompanied by extensive hepatization, Laennec advises Quinine, or Bark, in large doses. In Asthenic Pneumonia, the value of Quinine is forcibly pointed out by Dr. Corrigan.* The general dose is gr. v. every third hour: under its use the pulse becomes slow and steady, and the respiration free. If the patient be young, with evidence of capillary congestion generally over the system, its use is preceded by local depletion.

2334. In Laryngismus Stridulus, Dr

Merei states that, in six out of twelve cases in which he administered Quinine, the effect was equally sudden and satisfactory. *' It is chiefly useful," he observes, "in those weak and obviously nervous infants, who suffer for weeks or months from tits, but who, during the intervals, are free from all disease." It should be given in the largest doses that the child can bear, and during the intervals of the paroxysms. In Hooping-Cough, when the disease is protracted, and assumes an intermittent or periodic type, particularly a tertian form, Quinine or Cinchona should never be omitted. (Dr. Copland.) In the second or spasmodic stage of Hooping-Cough, Dr. Lecardre§; speaks highly of the modifying influence of Quinine. He gives it in powder from gr. iij. - gr. x. daily, according to the age of the child, each dose administered immediately after a paroxysm. The treatment of Croup by Quinine is advocated by Prof. Eastman. || He employs it in large doses, as there appears to be a great tolerance of the medicine. The only other measures he advocates are a full dose of Calomel and a warm bath.