2112. In Palpitations Arising From Hypertrophy Of The Heart, M

Salgues|| found that cases which resisted all other remedies were often greatly relieved by the Acetate of Lead, in doses of gr. ij. - vj. daily. Dr. Dunglison advises the following formula: -2112 In Palpitations Arising From Hypertrophy Of T 171 Plumb. Acet. gr. ij., MorphiAe Acet. gr. 1/3, M. ter in die sumend.

2113. In Dysentery, The Acetate Of Lead Proves Eminently Serviceable

Dr. Symonds¶ says, that for moderating the sanguineous discharge, no medicine, in his opinion, is comparable with it. "It should not," he observes, " be administered before depletion has been freely employed; but we have ventured to give it earlier than we should have dared to use any other astringent, believing that it exerts a sedative action upon the inflamed parts, independently of its styptic property." In numerous cases, particularly when the faeces are accompanied by a large discharge of mucus, I have found the Acetate, in doses of gr. iij. - iv. in combination with Dover's Powder (gr. iv. - v.), a remedy of great power and efficacy.

* Med.-Chir. Trans., vol. xiii. art.v. Archiv. Gen. de Med, 1839.

Ibid., Sept. 1839.

§ Diseases of the Heart, 3rd Ed., p. 478.

II Rev. Med-Chirurg., 1847. ¶ Lib. of Med., vo1 iv. p. 97.

2114. In Diarrha, It Also Proves Very Effectual

Dr. Golding Bird* found it very successful, given in doses of gr. ij. after every motion, until the quantity taken amounted to j. It is, however, seldom necessary to carry it to this extent. In two instances, the discharge was arrested after four or five doses: one was a case of Diarrhoea, supervening upon fever; in the other, it followed an attack of purpura. Dr. Theophilus Thompson employed it in one-grain doses, in Diarrhoea following Peritonitis. It quickly arrested the discharge, improved the pulse, and restored the patient to health. Dr. Graves considers that, in Diarrha, accompanied by Tympanitis, in the advanced stages of Fever, the Acetate of Lead must be our sheet-anchor. Dr. Copland§ states that he has derived benefit from it, in combination with Opium, in the Diarrhoea attending the advanced stages of Phthisis. In the obstinate Diarrhoea of children, Dr. Will-shire|| found the following formula highly serviceable; and I can speak from experience of the benefit which often results from a similar mode of treatment: -2114 In Diarrha It Also Proves Very Effectual 172 Plumb. Acet. gr. ij. - iv., Conf. Aromat. 3ss., T. Hyoscyam. ev., Mucilag. Arab, f 3ij., Infus. Gentian, fiss., M. ft. mist. Dose, f3j. - f3ij. after each stool: f3j. may be given to a child a year old. Conjointly with this, Turpentine enemas and the hot bath should be employed. The value of this salt in Diarrha and Dysentery has been much insisted upon by Drs. Burridge,¶ Sweeting,** Batchelder. and others.

2115. In Cholera, the Acetate of Lead, in combination with Opium, was first proposed by Dr. Graves. and, in many cases, decided improvement appears to have followed the use of his formula: -2114 In Diarrha It Also Proves Very Effectual 173 Plumb. Acet. j., Pulv. Opii gr. j., Conf. Ros. q. s. ft. pil. xij. Of these, one is given every quarter of an hour during the stage of collapse; and, in the other stages, every one, two, three, or four hours, according to the urgency of the case. Mr. Thorn §§ states, that when the disease broke out in his regiment in India, he found the Acetate (gr. ij. - iij.), in combination with Morphia (gr. 1/8), a most valuable remedy in checking the profuse watery dejections. It is chiefly applicable to the premonitory stage, and may be advantageously combined with

• Lancet, March 7, 1846. Ibid.

Clin. Lect., vol. i. p. 132. § Dict Pract. Med., vol. i. p. 535. || Lect. on Dis. of Children, Med. Times, vol. xvii. p. 251.

¶ Prov. Journ., June 25, 1851. ** Ibid., June 11, 1851. New York Journ. of Med, July 1851.

Clin. Lect., vol. i. p. 419. §§ Med Times, vol xvi. 1847, p. 151.

Camphor or Capsicum. It is a remedy well worthy of confidence.

2116. In Ulceration of the Stomach, the Acetate is often effectual, allaying in a remarkable degree all the attendant symptoms, at the same time that it assists in establishing a healthy state of the ulcerated surface. It is best given in doses of gr. ij. - iij., combined with MorphiAe Acet. (gr. 1/4 to 1/2).

2117. In Incarcerated Hernia, enemas containing the Acetate of Lead have been successfully employed by Dr. Huxthausen,* who relates three cases illustrative of its efficacy. The strength was 3j. of the salt to f vj. of water. This quantity was found sufficient in the majority of cases, but it may be repeated if necessary. In each of the three cases above mentioned, spontaneous re-position took place within five hours. The efficacy of this treatment is further attested by Dr. Neuhold, who relates several cases in which these enemas were attended with complete success. He found that from four to six enemas, each containing gr. x. of the Acetate, were the utmost required. They were repeated every two hours.

2118. In HAemorrhages, active or passive, whether proceeding from the Lungs, the Stomach, the Kidneys, the Nose, or other parts, the Acetate of Lead (gr. ij. - iv.), combined with Opium (gr. ss. - j.), proves signally useful. The auxiliaries are the external application of cold, acidulated drinks, perfect rest, and antiphlogistic diet.

2119. In Menorrhagia, the Acetate of Lead with Opium, as advised in the last section, is one of the most efficacious remedies which we possess. Dr. Dewees' estimate of it is very high. He advises the following formula: -2114 In Diarrha It Also Proves Very Effectual 174 Plumb. Acet. j., Opii gr. iv., M. ft. pil. xij. Of these, one is given every half-hour, hour, or two hours, according to the severity of the attack. Should this cause nausea or pain, he advises j. of the Acetate, f 3j. of T. Opii in f ij. of warm water, to be used as an enema; and it may be repeated if the first be soon returned. He adds, that taking a grain of the Acetate with a little Opium, three or four times a day, in the absence of the discharge, will be found highly useful.

2120. In Uterine HAemorrhage, with threatened Abortion, the Acetate of Lead, combined with Opium, is in some cases of signal benefit. For selecting those cases in which it is advisable to administer it, see Opium, sect. Abortion. If the bleeding be attended with inflammatory action, and the patient plethoric, venAesection should precede the use of astringents. The Acetate may then be given in the doses and manner advised in Menorrhagia.

* Brit. and For. Med. Rev., Oct. 1838. Monthly Journ. of Med., Feb.

On Diseases of Females, 6th Ed., p. 171.

2121. In HAemorrhage from the Bowels in the advanced stages of Fever, the cautious use of the Acetate of Lead and Opium with wine, are the only means on which we can rely with any confidence. (Dr. Graves.*)

2122. In Chronic Bronchitis accompanied by profuse secretion of Mucus, the Acetate of Lead is one of the most powerful remedies we possess. It is strongly recommended by Dr. Henderson, who obtained the best results from its employment in doses of gr. 1/4 to gr. j. eight or ten times a day for children, and gr. j. to gr. iij. for adults. The maximum daily dose is gr. xij. Dr. Theophilus Thompson observes that, in all cases of inordinate secretion from the bronchial tubes, the Acetate has proved signally efficacious.

2123. In the profuse Perspirations of Phthisis, Fourquier considered that this salt exercised an almost specific effect when given in doses of gr. iv., gradually increased to gr. xij. daily; but Louis administered it thus in twelve cases, and in one instance only did it prove successful. Sir James Clark found it more useful in diminishing the quantity of expectoration.§ In Asthenic Pneumonia, especially when occurring in debilitated subjects, the Acetate is highly recommended by Prof. Christensen: he prescribes it generally with Quinine, gr. j. of each every two hours. If the cough is very \iolent, Opium is substituted for Quinine. Dr. Bramsen has been very successful with it in the Pneumonia of Children. Dr. Brandes obtained equally favourable results, and extols particularly its calming properties in this disease. He prescribed it in doses of gr. 1/2 for children of one to eight years of age. || This treatment is very favourably reported of by Dr. Leudet, of Rouen:¶ of forty cases treated by the Acetate, thirty-seven recovered and three died. It seems well worthy of further trials.