2325. In Typhus Fever, Cinchona Was Introduced In 1770 By Dr

Miller, and was subsequently recommended by Dr. J. Clark. &c. In 1851, Dr. Dundas, from a fancied analogy between Typhus and Intermittent Fever, proposed the treatment of the former by large doses of Quinine. Much difference of opinion has been expressed as to its powers. That it failed in the Typhus of the Crimean war,where it was tried largely, is undisputed; and Dr. Murchison,* who is unfavourable to its use, observes: "One thing is certain, that there is no proof that Quinine can arrest the course of true Typhus." The ill effects occasionally observed have been increase of coma and delirium, and great depression of the vital powers. In Typhoid (Enteric) Fever, Dr. Murchison speaks very favourably of Quinine given as follows: -

2325 In Typhus Fever Cinchona Was Introduced In 17 198Quiniae Sulph. gr. 1/4 - gr. j., Acid. Sulph. Dil. vel Acid. Hydrochloric. Dil. exv. - xxx., Syr. Aurant. i3ss., Aq. Carui fj., M., ft. haust tertia vel quarts hora sumend. Though it has no power to cut short the fever, yet, under its use, the febrile exacerbations become reduced in severity, the appetite improved, and the strength increased. Much of the benefit is probably due to the acid. In Relapsing Fever, Quinine has been used with the view of warding off a relapse, but, like all other medicines, it has proved inoperative.

2326. In Puerperal Fever, Dr

Cabanellas employed Quinine in several cases with the best results. He premises the use of emetics and poultices to the abdomen, and then prescribes Quinine in doses of ten or fifteen centigrammes every hour day and night. It is to be hoped that further trials with this remedy will be made in epidemical forms of the disease.

2327. In Scarlet Fever and Exanthemata generally, when debility occurs, and the fever assumes a typhoid character, tonics are indicated; and of these, none is equal to Quinine given in combination with Acid. Sulph. Dil.; port wine and nutritious food being given at the same time. Cinchona has long been highly esteemed in these cases, and has the recommendation of De Haen, Sauvages, Cullen, and Percival. In Scarlatinal Albu-minuria, the remedy which has proved most effectual in the hands of Dr. Hamburgher§; is Sulphate of Quinine. It is not admissible in the early acute stage. Dr. Mouser|| considers that he has seen great benefit in Small-pox from the exhibition of Quinine (gr. ij. every three hours), from the commencement of treatment until all febrile symptoms had subsided and desiccation was fully established.

* On Fevers of Great Britain, &c, p. 262. Op. cit., p. 571. Med.-Chir. Rev., July 1862.

§ Archiv. Gen. de Med., April 1861. || Ranking's Abstract, xxxvii. p. 41. 1863.