Latin, Antipyrina (Gen., Antipyrinae)

Eng., Antipyrine. Synonym, Phenazone.

Form

Usually a colorless crystalline powder.

Odor And Taste

Almost odorless and tasteless.

Solubility

In less than 1 part of water. In 1.3 parts of alcohol.

Incompatibles

Acids and drugs containing tannic acid in appreciable amounts; alkalies, salts of iron, mercury, lead and arsenic; iodine and iodides; sodium bicarbonate and salicylate; alum, ben-zoates, phenol, cinchona alkaloids, resorcin,. spirit of nitrous ether, thymol, etc.

Average Dose

5 grains (0.3 Gm.).

Therapeutic Action

Antipyretic, sedative, analgesic.

Uses

Employed in the treatment of fevers, headache, neuralgia, whooping-cough, etc.

Administration

Antipyrine is so generally incompatible with other drugs that it is better to remember the few desirable agents with which it can be prescribed to advantage. This would include few others than caffeine, sodium bromide and flavored syrups. It is the most soluble of the common coal-tar antipyretics. It is prescribed alone in powders, capsules or in solution.

Antipyrine may be prescribed as:

Antipyrina Antipyrine 276

or

Antipyrinae..............................................................

gr. xl

2

5

Elix. Aromatici...................................................

q. s.Antipyrina Antipyrine 277

30

0

M.

Sig

Teaspoonful in water every two hours when necessary.

A frequent combination of antipyrine is shown in the following prescription for the paroxysmal stage of whooping-cough: For a child 4 years old:

Antipyrina Antipyrine 278

or

Antipyrinae...........................................................

3ss

2

Sodii Bromidi.....................................................

3j

4

Syr. Tolutani...................................................

q.sAntipyrina Antipyrine 279

60

M.

Sig

Teaspoonful in water every two hours until relieved.

Tinctura Belladonna; Foliorum is sometimes added.

As a hypnotic, analgesic, cough sedative and antispasmodic:

Antipyrina Antipyrine 280

or

Codeinae Sulphatis..........................................

gr.ss

03

Antipyrinae....................................

gr.xvj

1

00

Syrupi Aurantii.......................................

q.sAntipyrina Antipyrine 281

60

00

M.

Sig

Teaspoonful every two hours when needed. (Child 2 years old).

It is sometimes used by the physician as a local application, as in the following formula used by the rhinologist on cotton applicators to relieve congestion of the nasal mucosa:

Antipyrina Antipyrine 282

or

Cocainae Hydrochlor.....................................

.gr. v

3

Antipyrinae........................................................

gr.xv

1

0

Aquae Dest.....................

q.sAntipyrina Antipyrine 283

30

0

M.

Sig

Formula.

Apomorphinae Hydrochloridum

See Opium, p. 242.