Latin, Cocaina

Eng., Cocaine. An alkaloid obtained from Ery-throxylon Coca.

Average Dose

1/4 grain (0.015 Gm.).

Cocainae Hydrochloridum (Gen., Cocainae Hydrochloridi)

Eng., Cocaine Hydrochloride.

Form

Colorless prisms, flaky leaflets or white powder.

Odor And Taste

Odorless and having a bitter taste.

Solubility

In 0.4 part of water and 3.2 parts of alcohol.

Incompatibles

Alkalies, bromides, iodides, mercury salts, chloroform, etc.

Average Dose

1/4 grain (0.015 Gm.).

Cocaine Hydrochloride is used almost to the exclusion of all other preparations from coca.

Therapeutic Action

Local anesthetic, antiemetic, stimulant.

Uses

Chiefly employed to produce local anesthesia for surgical work; also used for pruritus, eczema, hemorrhoids, anal fissure, etc. Used to counteract unpleasant effects of other agents in the treatment of eye diseases, rhinitis, etc.

Administration

By Mouth.-It is not often prescribed in this way except to allay gastric irritability. The following will illustrate:

1 Ashton: Practice of Gynecology.

2 Shoemaker: Materia Medica and Therapeutics.

Cocaina Cocaine 611

or

Cocainae Hydrochlor............

gr. j

065

Acetanilidi.............

gr. x

650

Cerii Oxalatis................

gr. xx

1

300

M. ft. cht. no. iv.

Sig

One every two hours when indicated.

For Hypodermic Use

It is used either alone or with such agents as Sodium Chloride or Adrenalin Chloride. Hypodermic solutions are not ordered for the patient's use, and the physician frequently employs tablets to make the solution extemporaneously. They may be ordered as follows:

As a local anesthetic:

Cocaina Cocaine 612

or

Cocainae Hydrochlor.........

gr.j

065

Sodii Chloridi................

gr. iij

200

Adrenalin Chlor. (Sol. 1:1000)............

Cocaina Cocaine 613 v

300

Aquae Destil. Ster.................

q. s.Cocaina Cocaine 614

30

000

M.

Sig

Formula.

Unless the solution is for immediate use, the adrenalin should be omitted from the prescription, and added just before the preparation is employed.

To prescribe percentage solutions of cocaine:

Cocaina Cocaine 615

or

Cocainae Hydrochlor.............

gr. xviij

1

2

Aquae Destil. Ster................

q. s.Cocaina Cocaine 616

30

0

M.

Sig

Four per cent. solution cocaine hydrochloride.

Locally

Cocaine is frequently a constituent of local applications.

In the treatment of erythema venenatum:

Cocaina Cocaine 617

or

Cocainae Hydrochlor...............

gr. x

65

Adrenalin Chloridi (1:1000)............

Cocaina Cocaine 618

15

00

Aquae Rosae.......................

q.s.Cocaina Cocaine 619

180

00

M.

Sig

Apply every two hours.

l Ashton: Practice of Gynecology.

2 White and Martin: Genito-urinary and Venereal Diseases.

3 Ohmann-Dumesnil: Diseases of the. Skin.

In the treatment of conjunctival inflammation as.caused by foreign particles, etc.:

Cocaina Cocaine 620

or

Cocainae Hydrochlor...........

gr. ij

13

Adrenalin Chlor. (1:1000)..........

Cocaina Cocaine 621 v

30

Acidi Borici..............

gr. x

60

Aquae Destil. Ster.................

q. S.Cocaina Cocaine 622

30

00

M.

Sig

Drop in eye every three hours till relieved.

In the treatment of turgescent rhinitis:

Cocaina Cocaine 623

or

Cocainae Hydrochlor..........

gr. v

3

Antipyrinae.........

gr. xv

1

0

Aquae Dest................

q. s.Cocaina Cocaine 624

30

0

M.

Sig

For physician's use.

This is usually applied on long, slender rolls of absorbent cotton made by rolling cotton around a probe or applicator and then slipping it off. They are dipped into the solution and inserted in the nose and allowed to remain a few minutes.

In the treatment of erythema scarlatiniforme:

Cocaina Cocaine 625

or

Cocainae Hydrochlor............

gr. iv

26

Acetanilidi..........

gr. xx

1

30

Zinci Oxidi.............

3iss

6

00

Ung. Zinci Oxidi.........

q. s.Cocaina Cocaine 626

60

00

M.

Sig

Apply thin on a cloth.

In the treatment of herpes progenitalis:

Cocaina Cocaine 627

or

Cocainae Hydrochlor...........

gr. j

065

Mentholis.............

gr. xij

800

Adipis Lanae Hyd...............

q. s.Cocaina Cocaine 628

15

000

M.

Sig

Apply locally.

1 Ohmann-Dumesnil: Diseases of the Skin.

2 White and Martin: Genito-urinary and Venereal Diseases.

In the treatment of pruritus ani:

Cocaina Cocaine 629

or

Cocainae Hydrochlor...........

gr. x

65

Phenolis................

gr. xx

1

30

Petrolati.............

q. s.Cocaina Cocaine 630

30

00

M.

Sig

Apply locally.