Latin, Suprarenalum Siccum. (Gen., Suprarenali Sicci)

Eng., Dried Suprarenals (Glandulae Suprarenales Siccae, U. S. P., viii-Desiccated Suprarenal Glands).

The suprarenal glands of animals, which are .used for food by man, cleaned, dried, freed from fat, and powdered and containing not less than 0.4 per cent. nor more than 0.6 per cent. of epinephrin, the active principle of the suprarenal gland. One part of Dried Suprarenal represents approximately 6 parts of fresh glands, free from fat.

A light, yellowish-brown powder.

Average Dose

4 grains (0.25 Gm.).

Unofficial Preparation.

Epinephrina

Eng., Epinephrine. The blood-pressure-raising principle of the suprarenal gland.

Average Dose

7 l/2 minims (0.5 mil) of a 1: 1000 solution.

Therapeutic Action

Cardiac stimulant and vasoconstrictor.

Uses

Employed in solutions for local anesthesia. Extensively used for asthma, turgescent rhinitis, sinusitis, otitis media, nasal .or gastric hemorrhage, nausea, pulmonary edema, hemorrhoids, etc.

Administration

It should be particularly remembered that these preparations are incompatible with alkalies. The preparation under the trade name Adrenalin is extensively used in the form of the Solution of Adrenalin Chloride 1: 1000, Adrenalin Ointment, Suppositories, Inhalant, etc.

For systemic effect the drug is administered by needle.

The solution does not keep well, and for hypodermic purposes the aseptic ampoules are desirable.

1 Shoemaker: Materia Medica and Therapeutics.

For preparing small amounts of solutions for local anesthesia, tablets can be obtained (as of novocaine) containing the proper proportion of adrenalin.

The dried product, when employed, is usually administered in capsules.

As a nasal spray:

Suprarenalum Siccum Dried Suprarenals Glandulae Su 1290

or

Adrenalin Chlor. (Sol. 1:1000)...................

f3iss

6

Liq. Antiseptici...............................................

f3iij

12

Aquae................................................................

Suprarenalum Siccum Dried Suprarenals Glandulae Su 1291

90

M.

Sig

Use to spray nose every three hours.

This is much to be preferred to the common formula calling for the alkaline solution, which rapidly decomposes the adrenalin.

In a local anesthetic solution:

Suprarenalum Siccum Dried Suprarenals Glandulae Su 1292

or

Cocainae Hydrochlor......................................

gr. j

065

Sodii Chloridi...................................................

gr. iij

200

Adrenalin Chloridi (Sol. 1:1000)..............

mv

300

Aquae Destillatae..............................................

q. s.Suprarenalum Siccum Dried Suprarenals Glandulae Su 1293

30

000

M.

Sig

Formula.

Unless to be used at once, it is better to omit the adrenalin from the prescription, and add it immediately before using.

In the treatment of erythema venenatum:

Suprarenalum Siccum Dried Suprarenals Glandulae Su 1294

or

Cocainae Hydrochlor....................................

gr. x

65

Adrenalin Chloridi (Sol. 1:1000).............

Suprarenalum Siccum Dried Suprarenals Glandulae Su 1295

15

00

Aquae Rosae..................................................

q. s.Suprarenalum Siccum Dried Suprarenals Glandulae Su 1296

180

00

M.

Sig

Apply every two hours.