Strontii Bromidum. — Strontium bromide. Colorless, transparent, hexagonal crystals, odorless, and having a bitter, saline taste. Very deliquescent. Soluble in 1·05 parts of water at 59° Fahr. (15° C), and is readily soluble in alcohol. Dose, gr. v— 3 j.

Strontii Iodidum

Strontium iodide. Colorless, transparent, hexagonal crystals, and having a bitterish, saline taste. Soluble in 0·6 part of water at 59° Fahr. (15° C). Also soluble in alcohol. Dose, gr. v— 3 ss.

Strontii Lactas

Strontium lactate. A white, granular powder or crystalline nodules, odorless, and having a slightly bitter, saline taste. Soluble in about 4 parts of water at 59° Fahr.; soluble in alcohol. Dose, gr. v— 3 ss.

Antagonists and Incompatibles

As the salts of strontium form precipitates with solutions of the sulphates and carbonates of soda, potassa, and calcium, these are incompatible. The iodides and bromides are not incompatible with the same salts of the alkalies. As the salts of strontium are soluble in alcohol, they can be prescribed with alcoholic tinctures.

Synergists

The iodide and bromide of strontium promote the action of corresponding bases.

Physiological Actions

According to Laborde, who has made the most elaborate investigation of the actions of strontium, it is a non-toxic substance, and may be given in considerable quantity without causing any disturbance of a local or systemic character. Most of the salts, except the chloride, which appears to be innocuous, rather improve the appetite, promote the activity of the assimilation, and increase the body weight. The phosphate, however, more especially is a reconstit-uent—an agent having the power to increase the nutritive energies. The iodide and bromide of strontium have properties analogous to the corresponding salts of the alkaline bases, but they are more easily borne by the gastro-intestinal organs. The iodide possesses resolvent, discutient, or alterant properties. The bromide acts as a sedative to the nervous system. The evidence on this point is conclusive. If a solution of the bromide is injected into a member, it causes more or less complete anaesthesia, followed by infiltration and oedema. Administered in suitable doses, it causes somnolence, stupor, and paresis of the muscular system. It also lessens and finally extinguishes the reflexes, and it diminishes the sensibility of the mucous membrane. In fact, the bromide of strontium acts in a manner similar to the bromide of potassium, but it is far less depressing.

Most of the salts of strontium possess a diuretic property, but this is especially true of the lactate.

Therapy

In those disorders of the stomach characterized by acetic or lactic fermentation, loss of appetite, and nausea, the salts of strontium act favorably. When nausea of stomachal or cerebral origin is to be treated, the bromide is especially useful. When the nutrition is impaired because of loss of appetite and inactivity of the primary assimilation, great benefit may be expected from the use of the phosphate. Excellent results have been observed from the use of salts of strontium (nitrate and bromide) in the treatment of chronic rheumatism. Vulpian reported successful cases thus treated, in which the iodide of potassium and salicylate of soda had failed. He reports that under the action of the nitrate of strontium the swelling of the articulations rapidly subsided, that the local heat fell to normal, and the deposits of urates disappeared. This salt acts by promoting oxidation and increasing the excretion of urea.

The usual range of therapeutical activity exercised by the iodides of the other bases is equally the field of the iodide of strontium. The bromide is indicated and has been successfully used in the spasmodic neuroses, as epilepsy. Fere employed it in cases in which long use of the potash salt rendered the patient insusceptible to its action. He found it more useful, and he concludes hence that bromide of strontium should replace bromide of potassium in the treatment of that affection, especially when the latter has been long used.

It is especially as a remedy in Bright's disease that the salts of strontium are now used. When the symptoms of uraemia are due to insufficient urinary discharge, the lactate of strontium is indicated. According to Constantin Paul, the strontium salts give the best results in certain forms of nephritis—in parenchymatous nephritis, rheumatis-mal, gouty, etc.—but is not useful in interstitial nephritis. In these maladies from 8 to 10 grm. ( 3 ij — 3 iij) of the lactate may be given daily. Dujardin-Beaumetz has also made use of the lactate in the treatment of albuminuria, and obtained, uniformly, a reduction in the quantity of the albumin passed, but without completely arresting its excretion. He concludes that while it affects favorably the most important symptom, it does not remove the pathological condition. It has, however, the advantage over the other remedies for albuminuria, in that it promotes the appetite and the primary assimilation, and can be made use of for longer periods. Authorities referred to:

Coronedi, Giusto. Bromide of Strontium in Vomiting. The Practitioner, July,. 1892, p. 24.

Dougall, John. Strontium Bromide in Vomiting. The British Medical Journal, December 10, 1892.

Dujardin-Beaumetz. Journal de Pharm. Virchow u. Hirsch's Jahresbericht, 1891.

Egasse, Ed. Le Sels de Strontiane. Bul. Gén. de Thérap., November 30, 1891.

Gautier, A. Le Sels de Strontium Comme déplậteurs. Virchow und Hirsch's Jahresbericht, 1891.

Laborde, J. V. Etude experimentale de l'action sur l'organism das sels de Strontium. Ibid.

Raudnitz, R. W. Ueber die Resorption alkalischer Erden in Verdauungstract. Archiv fur experimentelle Pathologie und Pharmacologie, Band xxxi, p. 343.