Simple elixir, 16 fluidounces.

Quinine (alkaloid), 12 grains.

Cinchonine (alkaloid), 6 grains.

Mix the alkaloids, and triturate them in a mortar with one fluidounces of simple elixir, and then gradually add acetic acid in amount sufficient to effect their solution; then add the remainder of the simple elixir. Each fluidrachm (teaspoonful) of the finished elixir contains alkaloids sufficient to represent four grains of officinal calisaya bark. The preparation is that adopted by the American Pharmaceutical Association, 1875. The elixir has a distinct, bitter taste, and we have reason to believe that any substance which will overcome the bitterness will do so at the expense of the alkaloids, rendering them insoluble. Various plans have been recommended, from time to time, for detannating calisaya bark, usually by means of hydroxide of iron, first suggested by Mr. Meier, of New York, in 1867. These processes are tedious, and the product presents little, if any, advantage over a simple solution of the alkaloids. For this reason we consider this formula a practical substitute for "detannated elixir of calisaya," which follows.