Kobner recommends the following formula for patients who cannot support suppositories: 5380.

℞ Potassii iodidi....... gr. xxxxv

Potassii bromidi...... gr. xxxv

Extracti belladonnas.....gr. v

Aquae............ . ℥ vij

M. Mix each time, 6 drachms of this solution with from 2 to 4 ounces of hot water; at first once a day, afterwards twice daily.

Later on he increases the doses, and prescribes:

5381

℞ Potassii iodidi.........Э vijss

Potassii brotnidi.........Э v

Extracti belladonnae......gr. x

Aquas ............℥ x

Seven drachms of this solution in from three to four ounces of water, twice daily, by enema.

Kobner finds that by adding to each enema five to ten drops of pure tincture of iodine, the mixture is very efficacious and very well tolerated by the large intestines.

The author has used this method of treatment in certain hypertrophic metrites, as well as in syphilitic ulcerations of the rectum.

But he has more especially employed the treatment in syphilitics who could not support the internal use of the iodides. The therapeutic action of these enemas, even in doses of from seven to twelve grains has been very rapid. These enemas, combined with mercurial friction, may replace all other forms of medication, and are better supported than subcutaneous injections. - Gazette de gynecologic