"Nothing is conjectural now. The agent of the contagion is a living agent, already known for an important group of contagious diseases. This agent, this living element, we have been able to master, to observe it in the midst of artificials proper for its culture; we have been able to study its physiology, modes of existence; we have been able to subject it to profound modifying influences; to create, so to speak, races in different species. In short we have been able to see it by our own work in the living organisms, in conditions vigorously determined by the experimenters, and to study the series of effects that it is capable of producing.

After having torn away from nature this secret, so long a time guarded, that contagion is the function of the living element, that a certain number of contagious diseases is possessed of this element, they have isolated it from organisms where they had taken it, they have studied it in the midst of artificials proper for its development and to all the manifestations of its life; have submitted it to influences capable of moderating its energy, and in short have resolved this wonderful problem of transforming it, it the agent of death, into an agent of efficacious preservation which renders invulnerable those attacked by the natural contagion of the animals which have been submitted to the influence, mitigated by a systematic culture of the living element of this contagion; and this grand discovery of the attenuation of the virus that the entire world has applauded as one of the most wonderful acquisitions, the most marvellous that medical science has ever made perhaps; this discovery which in the capital of Scotland some months ago, and some days ago in the capital of Denmark, has yielded to M. Pasteur one of the grand triumphs which were formerly accorded to the conquerors in war.

Hydrophobia from the beginning of time to these last hours has lived a fatal disease, against which all attempts have ever and ignominiously failed, and here to day, thanks to M. Pasteur and his collaborators that he has associated in his work, it can be transformed into a disease wholly benig. nant, which not only is compatible with life, but still has this happy privilege of rendering invulnerable the organisms which have received the germ, in that state of benignity, against those harmed by its terrible virus, when they are inoculated in the natural conditions of intensity. To render hydrophobia as harmless a disease as carbuncle has become; what a marvellous problem is solved!

They knew positively that it was contagious, and that its exclusive mode of transmission was inoculation, which might be accidental, like that which results from a bite, the most frequent of all; it may be inoculation by the deposit of the foam of a mad animal upon an absorbing mucous, or wounded surface, or may be in short, experimental inoculation.

When they inoculate the monkey in successive series, the energy of the virulence follows a descending scale, of which the degrees can be measured by the increasing duration of the period in inoculation, and the attenuated hydrophobia of the monkey is transmitted to the dog or rabbit; the duration of the period of inoculation with these last animals is witnessed by the proportionate long increase of the attenuation of the virus which was inoculated to them. The application of these facts says M. Pasteur places in our hands a method of vaccinating dogs against hydrophobia.

Messieurs

This remedy, after which the victims of the bite of rabid animals have always looked forward to with so much ardor, the day is not far off without doubt, when M. Pasteur and others will be able to place it in the hands of physicians, and this remedy which is a very paradoxical thing, this will be the terrible virus itself removed by the wonderful method of attenuation of its deadly energy, will have been transformed in a vaccination against itself, and will bo able to invest the organism to which they inoculate it with a beneficent immunity, thanks to which the natural virus, inoculated by the bite, can no longer take effect on it". M. Bouley sums up as follows. -

Hydrophobia and Benignity!

Hydrophobia and Immunity !

Hydrophobia and Cure !