The art of foretelling results in diseases is called prognosis. To determine the probable end in many cases, is often important with reference to -treatment. The writer has deemed it wise to consider the signs on which prognosis is based, incidentally in connection with individual diseases. Some few obvious appearances which render the prognosis unfavorable, may here be mentioned: - Continued loss of flesh when connected with chronic affections is serious. Very feeble, rapid pulse, more especially in acute diseases, indicates a very grave condition. Among the fatal signs are a fixedness of the eyes, denoting paralysis; involuntary discharges, indicating great insensibitity. A jerking inspiration if not dependent upon diseases of the lungs, betokens death.