By James H. Salisbury, A.M., M.D.

Prize Essay Of The Albany Medical College Alumni Association, Feb., 1882. VII

I have made careful microscopic examinations of the blood in several cases of Panama fever I have treated, and find in all severe cases many of the colorless corpuscles filled more or less with spores of ague vegetation and the serum quite full of the same spores (see Fig. N, Plate VIII.).

Mr. John Thomas. Panama fever. Vegetation in blood and colorless corpuscles. (Fig N, Plate VIII.) Vegetation, spores of, in the colorless corpuscles of the blood. Spores in serum of blood adhering to fibrin filaments.

Mr. Thomas has charge of the bridge building on the Tehuantepec Railroad. Went there about one year ago. Was taken down with the fever last October. Returned home in February last, all broken down. Put him under treatment March 15, 1882. Gained rapidly (after washing him out with hot water, and getting his urine clear and bowels open every day) on two grains of quinia every day, two hours, till sixteen doses were taken. After an interval of seven days, repeated the quinia, and so on. This fever prevails on all the low lands, as soon as the fresh soil is exposed to the drying rays of the sun. The vegetation grows on the drying soil, and the spores rise in the night air, and fall after sunrise. All who are exposed to the night air, which is loaded with the spores, suffer with the disease. The natives of the country suffer about as badly as foreigners. Nearly half of the workmen die of the disease. The fever is a congestive intermittent of a severe type.

Henry Thoman. Leucocythaemia. Spleen 11 inches in diameter, two white globules to one red. German. Thirty-six years of age. Weight, 180 pounds. Colorless corpuscles very large and varying much in size, as seen at N. Corpuscles filled--many of them--with the spores of ague vegetation. Also spores swimming in serum.

This man has been a gardener back of Hoboken on ague lands, and has had ague for two years preceding this disease.

I will now introduce a communication made to me by a medical gentleman who has followed somewhat my researches for many years, and has taken great pains of time and expense to see if my researches are correct.