Shakespeare would appear to have had intuitive perception of the nature of such subtle poison, when he caused the ghost to describe to Hamlet

"The leprous distillment whose effect
Bears such an enmity to the blood of man
That swift as quicksilver, it courses through
The natural gates and alleys of the body
And with sudden vigor it doth posset
And curd like eager droppings into milk,
The thin and wholesome blood: so did it mine
And a most instant tetter marked about
Most lazar like, with vile and loathsome crust
All my smooth body."

It is not to be supposed, however, that all or even a major portion of the blood disks require to be changed or destroyed to produce a fatal result, since death may supervene long before such a consummation can be realized. It is the capillary circulation that suffers chiefly, since the very size and caliber of the heart cavities and trunk vessels afford them comparative immunity. But of the greatly dissolved and disorganized condition of the blood that may occur secondarily, we have evidences in the passive haemorrhages that attack those that have recovered from the immediate effects of serpent poisoning, following or coincident with subsidence of swelling and induration; and, as with scurvy, bleeding may occur from the mouth, throat, lungs, nose, and bowels, or from ulcerated surfaces and superficial wounds, or all together, defying all styptics and haemastatics. In a case occurring under the care of Dr. David Brainerd in the Illinois General Hospital,6 blood flowed from the gums in great profusion, and on examination was found destitute, even under the microscope, of the faintest indications of fibrine - the principle upon which coagulation depends.

The breath, moreover, gave most sickening exhalations, indicative of decomposition, producing serious illness in those exposed for any length of time to its influence. We may add, among other sequelae, aside from death produced through primary and secondary effects, paralysis, loss of nerve power, impotence, haemorrhage, even mortification or gangrene.

The failure in myotic power of the heart and in the muscles of respiration through reflex influence of par vagum and great sympathetic nerves, whereby pulmonary circulation is impeded, are among the earliest of phenomena. Breathing becoming retarded and laborious, the necessary supply of oxygen is no longer received, and blood still venous, in that it is not relieved of its carbon, is returned through the arteries, whereby the capillaries of the brain are gorged with a doubly poisoned circulation, poisoned by both venom and carbon. In this we have ample cause for the attending train of symptoms that, beginning with drowsiness, rapidly passes into stupor followed by profound coma and ultimate dissolution - marked evidence of the fact that a chemical agent or poison may produce a mechanical disease; and autopsical research reveals absolutely nothing save the general disorganization of blood corpuscles, as already noted.

Taking circumstantial and pathological evidences into consideration, the hope of the person thus poisoned rests solely upon lack of vitality in the serpent and its venom, and in his personal idiosyncrasies, habits of life, condition of health, etc., and the varied chapters of accidents. To look for a specific, in any sense of the word, is the utmost folly! The action of the poison and its train of results follow inoculation in too swift succession to be overtaken and counteracted by any antidote, supposing such to be a possible product, even if administered hypodermically. We have evidence of this in iodic preparations, iodine being the nearest approach to a perfect antidote that can be secured by mortal skill, inasmuch, if quickly injected into the circulation, it retards and restrains the disorganizing process whereby the continuity of the blood corpuscles is lost; moreover, it is a marked antiseptic, favors the production of adhesive inflammation, whereby lymph is effused and coagulated about the bitten part, and absorption checked, and the poison rendered less diffusible.

But when a remedy is demanded that shall restore the pristine form, functions, and energy of the disorganized globules, man arrogates to himself supernal attributes whereby it becomes possible not only to save and renew, but to create life; and we can scarce expect science or even accident (as some expect) to even rival Nature and set at defiance her most secret and subtle laws. Such, however, is the natural outcropping of an ignorant teaching and vulgar prejudice that feeds and clothes the charlatan and ascribes to savage and uncultured races an occult familiarity with pathological, physiological, and remedial effect unattainable by the most advanced sciences; and whereby the Negro, Malay, Hindoo, South Sea Islander, and red man are granted an innate knowledge of poisons and their antidotes more than miraculous. A reward of more than a quarter of a century's standing, and amounting to several thousand pounds, is offered by the East India Government for the discovery of a specific for the bite of the cobra, and for which no claims have ever been advanced; and the "snake charmers" or jugglers in whom this superior knowledge is supposed to center are so well aware of the futility of specifics, and the risk to which they are subjected, that few venture to ply their calling without a broad-bladed, keen-edged knife concealed about the person as a means of instant amputation in case of accident.

Medical and scientific associations of various classes, in Europe, Australia, America, even Africa, and the East and West Indies, have repeatedly held out the most tempting lures, and indulged in exhaustive and costly experimentation in search of specifics for the wounds of vipers, cobras, rattlesnakes, and the general horde of venomous reptiles; and all in vain. Even the saliva of man, as well as certain other secretions, is at times so modified by anger as to rival the venom of the serpent in fatality, and it has no specific; and a careful analysis of the pathological relations of such poison proves that further experimentation and expectation is as irrational as the pursuit of the "philosopher's stone."