Rue is mentioned in the Bible.1) As medicinal plant useful in the treatment of diseases of the eye, it is mentioned by Dios-corides,2) Pliny, Columella3) and Ovid.4) For like purposes the plant was used during the middle ages.6)

The first mention of oil of rue (although possibly of the fatty oil) is found in Saladin's writings.6) Gesner7) distilled the oil about the middle of the 16. century. It is mentioned in the price ordinances of the cities of Berlin for the year 1574 and of Frankfurt for the year 1582, and in the Dispensatorium Nor/cum of the year 1589.

The yield of volatile oil from rue was first determined by Cartheuser8) in the beginning of the 18. century. The oil was investigated by Caspar Neumann9) and by G. S. P. Mahl10) in Rostock in the year 1811, by Will11) in the year 1840, by Cahours12) in 1845, by Gerhard13) in 1848, by C. G. Williams14) in 1858, by W. Hallwachs15) in 1859, by C. Harbordt16) in 1862, by Giesecke17) in 1870, and by E. von Gorup-Besanez and Grimm18) in 1871.

1) St. Luke, 11:42.

2) Dioscoridis De materia medica libri quinque. Lib. Ill, cap. 45 and 52. - Editio Kuhn-Sprengel. 1829. Vol. 1, p. 391.

3) Columellae, De re rustica et de arbor/bus. Lib. XII, 7.

4) Ovidii Remedia amoris.

5) Pfeiffer, Zwei deutsche Arzneibucher aus d. 12. u. 13. Jahrh. Sitzungs-berichte d. kais. Akad. derWissensch. in Wien 42 (1863), 137 and 142. (Haeser, Geschichte d. Medizin. 1875. Vol. 1, p. 663.) - Milton's Paradise Lost. XI. line 414:

"- then purg'd with Euphrasy and Rue The visual nerve, for he had much to see."

6) Saladini Compendium aromatariorum. Bonona; 1488. Index.

7) Euonymi Philiatri Ein kostlicher Schatz. 1555. Fol. 226.

8). )oh. Friedr. Cartheuser, Fundamenta materia? medica?. Francof. ad Viadr. 1738. Vol. 2, p. 129.

9) Casp. Neumann's Medic. Chemie. Ed. C. H. Kessel 1749. Vol.2, p.292. 10) Trommsdorff's Journ. der Pharm. 20, II. (1811), 29. u) Liebig's Annalen 36 (1840), 235.

V1) These pre'sente'e a la Faculty des sciences le 15. janv. 1845. Compt. rend. 26 (1848), 262.

15) Liebig's Annalen 67 (1848), 242. u) Ibidem 107 (1858), 374.

") Ibidem 113 (1860), 107.

16) Ibidem 123 (1862), 293.

17) Zeitschr. fur Chemie 13 (1870), 428.

18) Liebig's Annalen 157 (1871), 275.