Oleum foliorum Jaborandi. - Jaborandiblatterbl. - Essence de Feuilles de jaborandi bark contains but very little volatile oil.

Jaborandi

Upon distillation the genuine jaborandi leaves2), from Pilocarpus Jaborandi, Holmes3) (family Rutaceae) yield 0,2 to 1,1 p.c. of volatile oil4) which has a decided odor reminding somewhat of rue and a mild, fruity taste. d16o0,865 to 0,895; aD +O°50' to -f3°25'. It is soluble in 11/2 to 2 parts of 80 p.c. alcohol, forming a clear solution, boils between 180 and 290° and congeals upon cooling.

1) Umney, Pharmaceutical Journ. III. 25 (1895), 796.

2) The leaves of Pilocarpus racemosus, Vahl, which is a native of the Antilles, are said to possess the same medicinal properties as the genuine jaborandi leaves. They yield a greenish oil with a strong and aromatic odor that becomes liquid at 25° (G. Rocher, Journ. de Pharm. et Chim. VI. 10 [1899], 236. Comp. also E. M. Holmes, Guadeloupe Jaborandi. Pharmaceutical Journ. 71 [1903], 713).

3) Pharmaceutical Journ. 55 (1895), 522, 539; 73(1904), 891,970; 84 (1910), 52.

4) Schimmel's Bericht April 1888, 44.

Fractionation yields a hydrocarbon named pilocarpene1) which boils at 178° (d18o0,852; [a]D + 1,21°) and which forms a solid dihydrochloride. This would indicate that pilocarpene is either dipentene or terpinene rendered slightly active by some impurity.

Fractions 260° plus congeal in the cold and contain a solid that melts at 21 to 28°. Apparently it is a hydrocarbon, probably of the olefinic series, since in petroleum ether solution it decolorizes considerable bromine2).