In acute disease, it is a favorable symptom if the patient falls asleep soon after taking the remedy; also, if he feels generally better, though the local symptoms may not show any improvement. The improvement here is probably largely psychical, and will soon be followed by the necessarily slower improvement on the physical plane.

The mental condition and general behavior of the patient, if more tranquil and natural, are among the most certain and intelligible signs of incipient improvement, especially in acute diseases.

Should this progressive evolution of the symptoms towards health cease,

A further review of the case is required, and a new remedy is to be chosen when -

(1) The mental state shows an embarrassed, helpless state instead of the tranquility of improvement.

(2) When no change of any kind follows the first prescription, after waiting long enough for reaction, which is, however, a variable matter, according to the chronicity of the case and character of the remedy chosen, the shortest period to be allowed in a chronic disease being one week, and preferably a longer time.

(3) When new and important symptoms and old modalities, especially aggravations that persist, characterize the case, proving that the remedy was not homoeopathic to the case, and acted only as a pathogenetic agent in producing new symptoms. This is the danger of selecting a remedy only remotely similar instead of the similimum. The second remedy will often be found a complementary drug of the first.