Great muscular debility is the most characteristic physical sign; anxiety; anguish; fear of associating with strangers; going into a crowd; great irritability; dysmenorrhcea, before, during and after flow, with great debility; sterility; inflammation of the Fallopian tubes, ovaries; neurasthenia; asthma; bronchial affections; distorted finger nails, eruption in the palms of the hands; dryness of the hair, etc.; rheumatism setting in shortly after the suppression of the discharge or removal of the warts; ankle and knee are specially affected; pains worse before a storm and during the day.