In acute cases, a dose every hour or two; in severe, painful affections, a dose every ten to fifteen minutes; in chronic affections, one to four doses daily.

In suitable cases the external use of the remedies is indicated and has been found useful. For this purpose the second or third and even the sixth trituration may be used.

In determining the dose of abiochemic remedy, the amount of the morbid product involved is no important factor. For instance, a very small deficiency of Natrum niur. in the cells of the epithelial layer of a serous sac may give rise to a massive serous exudation; and as minute a supply of Natrum mur. corresponding to the deficiency may bring about a complete resorption of the exudation.

Guided by the relative quantities of the cell salts, each practitioner can select the proper dose of the indicated bio-chemic remedy.

One milligramme (1-100 grain = to the 2d decimal trituration) of a substance is estimated to contain 16 trillions of molecules. According to this estimate, the 6th decimal trituration of it would contain about 16 billions; this quantity is more than sufficient to restore disturbed molecular motions to the normal.

It may be urged as an objection that the molecules of a given salt administered as a medicine would unite with their like contained in the blood, and thus render illusory any curative attempt. But this combination cannot take place simply because the carbonic acid present in the blood forms an isolating medium of the salts.