The steadily increasing demand for this work has exhausted three large editions and necessitated the preparation of a fourth edition. What was intended originally as a mere suggestive guide to the use of a set of valuable remedies has developed by the demands of the profession into a volume comprising the whole of our present therapeutic knowledge of the so-called Twelve Tissue Remedies.

Compilation largely from every available source has to supplement the authors' personal experience and knowledge of these remedies. All the published data have been made use of but thoroughly sifted and critically examined. Thus presented, we believe this fourth edition will be found a reliable guide to the use of the Tissue Remedies in disease, not only as far as possible, according to the distinctive theory of Schussler, as corrected and modified by him up to the time of his death, but especially according to the finer and more discriminating method of Hahnemann. Seven German editions of Schussler's "Abgekurztc Therapie" have been published since the last edition of this work was issued, the therapeutic development of these remedies has made wonderful strides, and our periodical literature during the past few years has contained many records of cures wrought by them. All this has been incorporated and this work, in its present complete and revised form, is the only adequate presentation of the therapeutic possibilities of the Tissue Remedies in our school.

We trust that the same consideration accorded to previous editions will be extended to this by an indulgent profession.

William Boericke. M. D.

San Francisco, Cal.

W. A. Dewey. M. D.

Ann Arbor, Mick. January I, 1899.

Preface To First Edition

The following treatise on the Twelve Tissue Remedies contains all that Schussler himself wrote on the subject, and embodies as well the whole published experience of the homoeopathic school in their use, besides much original matter from some of our homoeopathic practitioners now published for the first time. Our aim has been to give to the profession a complete work on the subject, because we recognize the great value and importance of the Tissue Remedies, and in doing this our work necessarily was one mostly of compilation and arrangement. Every available source from the whole of our journalistic literature and Society proceedings has been made to pay tribute to us; and however imperfect, fragmentary and crude the present work is, we know that it is complete, so far as present circumstances will permit.

We believe that the only hope for the future development of these magnificent remedies lies in their study, mainly according to the method of Homoeopathy; that they should all be as carefully proved as Natrum mur. and Silicea already are, and that the results of such provingg alone will furnish the most accurate indications for their therapeutic uses. Only by careful provings will the permanency of these remedies be secured, and they themselves be preserved from the possible fate of so many newly introduced remedies.

Thorough and systematic proving of drugs on the healthy is the one true method for the development of our Materia Medica: but this, from its very excellence, is a thing of slow growth, and the temptation could not be resisted to seek other and shorter methods, always more or less questionable, but sometimes yielding admirable results. The most important of such deviations from the Strictly classical method of proving on the healthy was the acceptance of Clinical Symptoms; used cautiously, this source can be of inestimable value, as much of our clinical experience proves.

Why may not the same results follow, by accepting tentatively, and for the time, Schussler's theories of the respective spheres of actions of his remedies and the indications based thereon, which, to say the least, are bold and often brilliant recommendations for their employment in disease?

Here, in the absence of regular provings of them, we can avail ourselves of this source and enrich our Materia Medica with some remedies that will compare favorably with many polychrests.

Whatever opposition there may be in our ranks to Schussler's methods, because it is not pure homoeopathic practice, we believe would speedily disappear if all critics could join in proving and confirming these valuable remedies, introduced first to American Homoeopathy by our own Hering, who surely could not be accused of fathering and furthering anything absolutely mongrel and detrimental to the best interests of our school.

We do not sympathize with the attempt of Schussler and a few others to look upon the Tissue Remedies as being sufficient for all purposes - provings alone can verify this. For the present, we think, with Dr. J. C. Morgan, that Schussler throws away a great and necessary complement to his Materia Medica in discarding all organic drugs, as Bellad., Hyos., Acon., etc , which really make the Tissue Remedies more valuable, acting as the opposite blade of the scissors; without these they would often remain incomplete in curative action and might be blamed for the inevitable. We, therefore, have included in our study of the Materia Medica the homoeopathic relationship, at present merely suggestive, but a department which, we hope, will be greatly enlarged at some future time.

To those who, by kind encouragement and contributions of clinical cases and observations, have given us valuable assistance in the preparation of the present volume, we desire to express our gratitude and indebtedness, prominent among whom are Prof. Samuel Lilienthal, who kindly placed his valuable library at our disposal; Professors J. C. Morgan, S. Powell Burdick, C. B. Currier, Henry C. Houghton, Wm. E. Leonard, and Drs. Horace F. Ivins, C. E. Fisher, A. P. Davis, I. E. Nicholson, G. H. Martin, and many others whose names are mentioned throughout the work.

William Boericke, M. D.

W. A. Dewey, M. D. San Francisco, Jan. 2, 1888.

Preface To The Second Edition

The present edition has been thoroughly revised and enlarged by the addition of all the facts relating to the Tissue Remedies that have accumulated for the past two years. In its present state, the book represents the complete presentation of the Biochemical Treatment of Disease by means of the Twelve Tissue Remedies. In order not to increase unnecessarily the bulk of the volume, a number of the clinical cases of the previous edition have been omitted, to make room for new matter and fresh clinical illustrations by the best authorities. The Materia Medica part of the work has been brought up to date by the incorporation of the results of late provings, and we feel indebted especially to Dr. H. C. Allen, of the Medical Advance, Hering's Guiding Symptoms, and Prof. T. F, Allen's magnificent work, the Handbook of Materia Medica, which include much of interest about these remedies. These Tissue Remedies are too precious to be used only on the pathological indications laid down by Schussler: they all merit careful proving in order to obtain the finer and more distinctive points for their therapeutic application; this has been done with several, and will undoubtedly be carefully done with all.

Not until then will the Twelve Tissue Remedies take their rightful position permanently in our Materia Medica, and prove to be polychrests of the highest order.

We trust that this work, in its present revised form, will meet with as favorable reception as was accorded to the first edition. William Boericke, M. D. W. A. Dewey, M. D.

San Francisco, Jan. 2, 1890.

Preface To The Third Edition

The generous reception and treatment accorded by the profession to the previous editions of this work rendered the preparation of a new edition a pleasant task. The whole work has practically been rewritten and considerably enlarged. Everything that Dr. Schussler himself has written up to the publication of his latest, the eighteenth edition of his "Abgekurzle Therapie" is included, together with much clinical experience by the homoeopathic profession, account of which is scattered throughout our journals and society transactions. The work is thus as complete as it can be at the present time regarding everything pertaining to the Biochemical treatment of disease and its relation to Homoeopathy.

Our conception of the true place of the Tissue Remedies has separated us more and more with each new edition from that of their distinguished introducer. While we have abided by his first conception, and endeavored to further their development along the lines of Homoeopathy, Schussler prefers now to look upon the Biochemic method as entirely distinct from Homoeopathy, and as an all-sufficient therapeutic procedure and chemical hygiene. Thus, while he relies solely on the chemico physiological facts and theories as guides for the therapeutic application of his remedies, we, accepting and utilizing all these, add thereto the indications derived from provings - the only legitimate and permanent basis for drug selection in disease. On this account, Dr. Schussler notwithstanding, we believe that careful provings of these remedies in all potencies should be made by our school. To some extent this has been done since the publication of our second edition, notably of Kali p/tos., an excellent account of which has been published by Prof. H. C. Allen, M. D., in the Medical Advance, the salient features of which are included in our account of that remedy.

In conclusion we wish again to thank the friends who have so kindly and disinterestedly helped the preparation of the present volume by furnishing us with clinical material and observations.

William Boericke, M. D. Willis A. Dewey, M. D. San Francisco, Sept. 1t 1892.