This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
Northern Europe and Asia.
Dose, 1/16 to 1/3 gx.; .01 to .02 gm.
Adonidin markedly increases the arterial pressure while decreasing the pulse rate. The primary rise is chiefly of cardiac origin, the slowing of the rate is due to stimulation of the inhibitory nerves. The late fall of blood-pressure is due, at least in great part, to vaso-motor paralysis. In its action it is more prompt than digitalis, and, according to Durand, does not have a cumulative action. If it is diuretic, it is chiefly through its effects upon the circulation. It is used for the same class of cases as digitalis. Its irritating properties prevent its subcutaneous use and even prolonged administration by the mouth.