B. If strong carbolic acid be applied to the surface of the skin, an immediate tingling and burning sensation is experienced; the spot affected becomes white, the neighboring skin displays a red areola, and the symptoms are similar to those attending the application of a powerful caustic. In the course of a few days there is exudation from the surface attacked by the acid. The irritation persists for a fortnight or three weeks. A more superficial application of the acid is found to diminish the sensibility of the skin so much that incisions into the part, and even the application of caustic potassa, give but little pain, 10, 1: 778. Anaesthesia, 9, 310; Wilson 135, 4: 5.

C. Pruritus, Binz, 114, no. 43, '70, 522; Kohn, 111, 1: 234; Guntz, 111, 1: 631; Rezek, 176, Sep. 3, '76. Psoriasis, Rezek, 176, Sep. 3, '76; Kohn, 111, 1: 234; Liveing, 137, 1/70, 602; 56, 153; 98, 68.

C & D. Pruritus, prurigo, and psoriasis, 210.

D. Acne, Brown, 116, 2/78, 162.

Eczema, 5, 265; 17, 1228; Coleman, 137, 1/69, 292. Psoriasis, 5, 265; 17, 1228; McNab, 137, 1/70, 408. Pruritus, 5, 265; 17, 1228; 97, 1: 103; 201; 203. Trichophytosis, Rhodes, 116, 2/77, 106; Cottle, 116, 2/77, 136. Hypendrosis, 98, 44. Lupus erythematosus, 97, 2: 319. Lupus vulgaris, 97, 2: 371. As a local anaesthetic, 201. Rhus poisoning, 203. Furuncle (a drop of the pure acid inserted in the suppurating cavity),

Remarks

The fact that carbolic acid mixes well with water, alcohol, glycerine, oil and fats, has led to its very frequent use in cutaneous diseases, and it has certainly been found useful when administered internally in some cases of pruritus of obscure origin, and of psoriasis which have resisted other means. It may be given in water or glycerine, or made into pills with soap, in doses of one to five grains daily. In larger doses its effects must be very carefully watched, as poisonous symptoms may suddenly develop. Externally it may be freely used if diluted, but symptoms have arisen even when thus employed. The officinal preparations are: Aqua Acidi Carbolici; Glyceritum Acidi Carbolici; Suppositoria Acidi Carbolici; and Unguentum Acidi Carbolici.