A. A fine pustular eruption sometimes appears upon the skin, 10,1: 272.

B. Applied to the skin causes, in a few seconds, a much greater pain than any other acid. If it be immediately washed off, some burning remains, and the skin turns white, and later yellow, 43, 196.

C. Psoriasis, impetigo, acne, erythema nodosum, and other eruptions in which the skin affection is symptomatic of imperfect digestion and assimilation, 4, 67. Pemphigus, 86, 1: 277. Syphilis, Rodgers,* 202; 208; 210; (H.G.P.).

D. Cancerous ulcers, hospital gangrene, chronic eruptions, 1, 964-5. Naevus, 203.

Chancroids. Condylomata.

Remarks

In cases of long standing or relapsing eczema, when accompanied with imperfect assimilation and urinary deposits, nitric, as well as the other mineral acids, is sometimes of decided service. At one time it was much used in tertiary syphilis, but gradually fell into unmerited oblivion. Dr. .John R. B. Rodgers (loc. cit.) speaks of it as follows: "The nitric acid, by administering a considerable quantity of oxygen, and by acting on the glandular system, assisted the operation of mercury. It is only when the system is disoxygenated that nitric acid is of service. I cannot say that I ever saw the nitric acid of itself, and without the use of mercury, cure large and extend. syphilitic ulcers; although 1 have seen it remove ulcers which a continued use of mercury could not overcome. In these cases the venerea1 virus had been destroyed, and | ulcers were kept up from irritability and debility of the part and of the system." Whatever may be the explanation, nitric acid internally administered, even in quite small doses, will sometimes cheek the progress, and promote. the healing of syphilitic ulcerations that fail to respond to the usual doses of the more commonly employed specifics, mercury and iodide of potassium.

Externally, its most frequent application is as a caustic to chancroids, mucous patches, condylomata, and ordinary verrucas. It is also frequently employed in phagedenic ulceration and solughing wounds. In chancroids it yields in in efficacy, we think, to nitrate of zinc, and in rapidly extending ulcerations, to bromine.due. In France the "pommade oxygenee" (nitric l part; simple ointment, 10 parts) is sometimes employed in oh Beside the pure acid the only officinal preparation cum Dilutum.

*Transactions of the Medical Society of the State of New York, 1813. Reprint, page 68.