Xanthoma is considered by some to be a neoplasm, but to my mind it is a special reaction of the skin brought about by one or more agents. We see one form occurring in various liver affections associated with jaundice, e.g. gall stones, and the xanthoma may disappear with the removal of the gall stones and jaundice. I have seen a hypertrophic cirrhosis of the liver become quiescent and the liver diminishing with gradual disappearance of the xanthoma, suggesting the cessation of manufacture of some toxic agent. Then we have forms of xanthoma associated with glycosuria and diabetes, and lastly eruptions without evident cause. What the toxic agent common to all these conditions is we do not know. The xanthoma of glyco-surics and diabetics is strikingly affected for the better by special diet.