Sprue is a disease belonging to this group which should have special mention. It is a chronic and insidious catarrh affecting the whole of the alimentary canal. It occurs chiefly in adults who have resided in tropical countries. Its origin is unknown, but it is believed to be due to bacteria. It is a troublesome and serious affection, often lasting for years, producing emaciation and great weakness by the persistent diarrhea which is its chief feature. For this disease it is sometimes recommended that milk alone should form the diet; it must be taken in a quantity sufficient to support the nutrition of the body - that is to say, not less than four pints and usually five pints daily. There are, however, diversities in the treatment. One authority recommends the addition of strawberries and another medlars to the diet. Manson, who is one of the greatest living authorities on tropical diseases, says milk diet is the best to begin with, but it should not slavishly be adhered to. Thin recommends the consumption of two or three pounds of fresh ripe strawberries a day; Mercier says the consumption of three-quarters of a pound of soft, not over-ripe medlars a day will cure the disease. The patient should be kept in bed until these fruits can be added to the diet. As the stools become normal we may gradually add raw eggs, rice milk, jelly, chicken panada, raw scraped meat, and gradually build up a dietary such as would be given in other cases of intestinal catarrh. Cantlie recommends that the treatment should be begun by a meat diet; he prescribes raw meat juice, plain jelly, and scraped meat sandwiches, to be given in small quantities every fifteen minutes. As the weakness subsides he makes the intervals of feeding longer and the amount of food greater, until at the end of a week the patient has four or five ounces of beef minced in a machine three times a day. At this time he allows some of the meat to be lightly cooked over a fire. Between the meals he orders jelly, and some rice boiled and steamed until it is dry. After two weeks he allows a slice of tender meat from any joint, underdone roast beef being the best; but beef or mutton, boiled chicken, and light fish are all allowed. "Pulled bread" is allowed after two or three weeks. Boiled celery, boiled lettuce, vegetable marrow, seakale, and spinach are now allowed. Strawberries may be taken between the meals. Some red wine, old port, Hungarian, whortleberry or barberry wine are recommended; and toddy made from the fermented juice of the cocoanut palm; the latter is said to be a specific for chronic diarrhea, dysentery, and intestinal catarrh.