Men are oftener assailed by this dangerous disease than women. This may be accounted for, in part, by the well-known fact that one of the most active causes of apoplexy is the intemperate use of fermented liquors, which, in some constitutions, produce a speedy impairment of the functions of the brain. Alcohol also exerts a pernicious influence in many instances upon the heart and arteries. The heart's action is not only increased under its influence, hut positive alterations in the structure of the bloodvessels take place. In such instances, we find the movements of the heart permanently quickened, and the blood, therefore, driven more forcibly to the brain, while the coats of the arteries having lost their elasticity by a thickening or thinning (perhaps ulceration) of their substance are more readily ruptured by this forcible current, and hence the tendency to hemorrhage in the brain is vastly increased. The excessive use of tobacco is also supposed to predispose to congestion of the brain, and consequently to apoplectic attacks. As the excessive employment of alcohol and tobacco are essentially vices of the male sex, we may attribute to them, in part, the greater liability to apoplectic attacks to which men are the victims.