The statistics of rheumatic affections show that, prior to the age of forty, more men than women die from rheumatic inflammations. After the age of forty, a curious change takes place in this respect. The female constitution is so altered that she becomes the one most readily affected with this malady. From forty to sixty more women die than men from the direct and indirect effects of rheumatic fever and inflammation of the joints. This much greater frequency of the disease in women after the change of life has been ascribed to the greater tendency of the skin to perspire, and hence the greater danger of checked perspiration.