SYMPTOMS: Vaccinia begins after inoculation with slight irritation at the site of vaccination. On the third or fourth day the eruption appears in the form of a red papule, surrounded by a red areola. On the fifth or sixth day the papule becomes a vesicle, being filled with a watery substance or a clear substance, with a distinct central depression (unbilication). By the eighth day the vesicle is perfected and is then surrounded by a wide reddened zone of inflammatory edema, which is the seat of intense itching. By the tenth day the contents are purulent (pus) and the vesicle has become a pustule. The surrounding skin is now much inflamed and painful. About this time the reddened areola begins to fade and dessiccation sets in with the gradual formation of a thick brown crust or scab, which becomes detached and falls off about the twenty-first to twenty-fifth day, leaving an ugly scar. The scar is at first red but gradually becomes paler than the surrounding skin; having a punched-out appearance and is pitted.

The evolution of this pathology is accompanied with fever and constitutional symptoms, malaise, and enlargement of the adjacent lymph nodes or glands.

Notice the symptoms above described (and this description is gathered from standard medical works) and you will at once realize that we have been describing an acute disease--really the acute symptoms of septic infection. Vaccinia will be found classified in medical books as an "acute infectious disease."

The infectious matter is pus taken from pustules on a cow which has previously had pus from the pustules of a smallpox patient rubbed into incisions in her skin. It is a morbid product, a Virus, and is not and never was "lymph from the calf." Vaccine is pus--it is the fluid product of suppuration.

To vaccinate a person is to produce disease in that person. It is an effort to prevent disease by producing disease. It does not always "run true to form." The above description of the disease does not fit all cases.