In addition to the part that the submucous areolar tissue takes in inflammation of the mucous membrane of the air-passages, it is also subject to inflammations, occurring as primary affections. These inflammations are, however, rare, and for the most part of a metastatic character; and hence they have a special tendency to run into suppuration and necrosis of the areolar tissue and mucous membrane. In reference to their position and diffusion over the air-passages, they are usually limited to the submucous areolar tissue of the larynx; they may, however, extend to the corresponding tissue in the throat and pharynx, and even into the intermuscular areolar tissue of the neck. As results of chronic inflammation, we often in the larynx, meet with hypertrophy, thickening, and callous induration of this tissue, and a consequent narrowing of the cavity of the larynx.