This term is used for a simple chronic inflammation in connection with prolonged irritation of the glands. This is most directly produced by the introduction of foreign substances, where the solid particles are conveyed to the glands (see above). It occurs also in connection with prolonged peripheral irritation, as where an eczema of the leg or the scalp produces an enlargement of the corresponding glands. The inflammation here results in increase of the entire elements of the gland, or else in a preponderating increase of the connective-tissue stroma with atrophy of the proper gland-tissue and induration of the gland.