This section is from the book "Research In Physiopathology As Basis Of Guided Chemotherapy With Special Application To Cancer", by Emanuel Revici. Also available from amazon: Research In Physiopathology
The influence of age of a host upon the different manifestations through the intervention of sterols and lipoacids can be seen in the following experiments.
Transplants from the same Walker tumor were grafted at the same time in animals of different ages, such as newborn, weanlings, young animals, adults and aged. The difference between transplants was evident even from the beginning but was still more enhanced if further transplants were made in animals under similar conditions. After one transplant and especially after several transplants, the following changes could be seen. In the newborn, the tumor took on the aspect of an hemangiomatous lesion. There was no massive tumor and the amount of blood present gave the tumor the appearance of a piece of liver. In weanlings, the character was opposite. Massive tumors without necrosis and with the aspect of fish meat were seen. In youngsters the same character was obtained. In adult animals, the tumor had a large portion of necrosis with predominance of hemorrhagic fluid. In very old animals, this character was still more accentuated, and the tumor showed big cavities with hemorrhagic fluid and very little tumor substance between.
Similar changes were obtained by changing the site of the graft. By grafting a portion of the same tumor, intramuscularly, we obtained a massive whitish, nonnecrotic tumor, while subcutaneous injection even in the same animal led to the appearance of a tumor with multiple necrotic areas and cavities filled with fluid.
We tried to correlate these changes with the nature of different lipids predominant at different ages. The administration of fatty acids tends to promote necrosis, edema, and formation of cavities filled with fluid, while administration of insaponifiable fractions, especially from placenta or liver, tends to produce a type of tumor with whitish, nonnecrotic masses.
The relationship between epidemics and seasons is a well established concept. In an attempt to explain this correlation, we considered, as one of the intervening factors, the seasonal changes in lipids, in view of the influence exerted by the two opposite groups of lipids upon the receptivity and manifestations of infectious disease.
As we have mentioned, viral infections are especially influenced by the predominance of one or the other group of lipids in the body. Among other factors, temperature changes were found related to this predominance. A relatively direct correlation was found for polio, for instance. The appearance of neurological symptoms such as paralysis was seen to increase on days with high temperature. Such a correlation could be established experimentally. Among mice injected subcutaneously with smallpox vaccine and kept in an incubator at 35° C, the incidence of encephalitis rose to more than 90% as compared to 10% in controls kept in an air conditioned room. This correlation was further explained by the predominance of sterols in the organism under the influence exerted by high temperature. This predominance was further seen to induce a higher receptivity of the organism to viral infection, and a change in the virus virulence itself, both of which increase with temperature and with the richness of sterols.