The first work embodying such record is that of Hahnemann, entitled Fragmenta de Viribus Medicamentorum Positivis. It is a Latin work, and published in Leipsic in 1805. Twenty-seven drugs are treated of, containing symptoms Hahnemann himself had observed as effects of poisoning or from excessive dosing, and of provings on himself. * "I have instituted experiments," he says in the preface, "in chief part on my own person, but also on some others whom I knew to be perfectly healthy and free from all perceptible disease".

"In those experiments which have been made by myself and my disciples, every care has been taken to secure the true and full action of the medicines. Our provings have been made upon persons in perfect health, and living in contentment and comparative ease. When an extraordinary circumstance of any kind - fright, chagrin, external injuries, the excessive enjoyment of any one pleasure, or some event of great importance - supervened during the proving, then no other symptom has been recorded after such an event, in order to prevent spurious symptoms being noted as genuine. When such circumstances were of slight importance, and could hardly be supposed to interfere with the action of the medicine, the symptoms have been placed in brackets, for the purpose of informing the reader that they could not be considered decisively genuine".

* It is interesting to know the names of the pioneer medicines whose pathogenic effects were first published in this work of Hahnemann. They are Aconitum, Arnica, Belladonna, Camphora, Cantharis, Capsicum, Causticum, Chamomilla, Cinchona, Coccu-lus, Copaiva, Cuprum, Digitalis, Drosera, Helleborus, Hyoscy-amus, Ignatia, Ipecacuanha, Ledum, Mezereum, Nux vomica, Opium, Pulsatilla, Rheum, Stramonium, Valeriana, Veratrum album. Of these, Cantharis, Copaiva, and Valeriana, Hahnemann did not include in his subsequently published "Materia Medica".